Search for dissertations about: "Niclas Jonsson"

Showing result 1 - 5 of 8 swedish dissertations containing the words Niclas Jonsson.

  2. 1. Methodological studies on non-linear mixed effects model building

    Author : E. Niclas Jonsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Abstract : Population analysis of pharmacokinetic/pharmacodynamic (PK/PD) data by the use of non-linear mixed effects modeling offers a number of benefits over traditional methods of analyzing this type of data. These benefits include the possibility to appropriately characterize the typical PK/PD behaviour in the population as well as the associated variability when only a few observations are available for each individual. READ MORE

  4. 2. Role of the Blood-Brain Barrier in Stereoselective Distribution and Delay in H1 Receptor Occupancy of Cetirizine in the Guinea Pig Brain

    Author : Anubha Gupta; Margareta Hammarlund-Udenaes; Niclas E. Jonsson; Joseph W. Polli; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Cetirizine enantiomers; Brain distribution; Microdialysis; H1 receptor occupancy; Stereoselective-pharmacokinetics; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

    Abstract : Cetirizine, an H1-antihistamine, is prescribed for allergic disorders. It exists as a racemic mixture, with levocetirizine being the active enantiomer. The central nervous system side-effects of H1-antihistamines are caused by their penetration into the brain. READ MORE

  5. 3. Pharmacometric Models for Individualisation of Warfarin in Adults and Children

    Author : Anna-Karin Hamberg; Mia Wadelius; E Niclas Jonsson; Lena E Friberg; Jeffrey S Barrett; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; warfarin; pharmacokinetics; pharmacodynamics; pharmacometrics; pharmacogenetics; dose individualisation; children; Klinisk farmakologi; Clinical Pharmacology;

    Abstract : Warfarin is one of the most widely used anticoagulants. Therapy is complicated by warfarin’s narrow therapeutic range and pronounced variability in individual dose requirements. Although warfarin therapy is uncommon in children, it is crucial for children with certain congenital or acquired heart diseases. READ MORE

  6. 4. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials

    Author : Kristin E Karlsson; E Niclas Jonsson; Mats O Karlsson; Anders Grahnén; Michael K Smith; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; model-based analysis; pharmacometrics; modeling; disease progression; NONMEM; SAEM; Importance sampling; repeated time-to-event; RTTCE; RCEpT; NIH stroke scale; Barthel index; internal validation; external validation; study power; study design; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. READ MORE

  7. 5. Development, Application and Evaluation of Statistical Tools in Pharmacometric Data Analysis

    Author : Lars Lindbom; Niclas Jonsson; Mats Karlsson; Pascal Girard; Uppsala universitet; []
    Keywords : Pharmaceutical biosciences; pharmacometrics; pharmacokinetics; pharmacodynamics; methodology; statistics; model evaluation; resampling methods; Farmaceutisk biovetenskap;

    Abstract : Pharmacometrics uses models based on pharmacology, physiology and disease for quantitative analysis of interactions between drugs and patients. The availability of software implementing modern statistical methods is important for efficient model building and evaluation throughout pharmacometric data analyses. READ MORE