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Showing result 1 - 5 of 11 swedish dissertations matching the above criteria.

  2. 1. The glycobiology of human adenovirus infections : implications for tropism and treatment

    Author : Naresh Chandra; Niklas Arnberg; Lars Frängsmyr; Gunnel Haldén; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; denovirus; cellular receptor; glycosaminoglycan; sialic acid; decoy receptors; tropism; epidemic keratoconjunctivitis; antiviral drugs; GAG-mimetic; obesity; medicinsk virologi; Medical Virology;

    Abstract : Human adenoviruses (HAdVs) are common human pathogens, causing gastrointestinal, ocular, and respiratory infections on a regular basis. Epidemic keratoconjunctivitis (EKC) is a severe ocular infection for which no approved antivirals are available. READ MORE

  4. 2. Rotavirus Disease Mechanisms Diarrhea, Vomiting and Inflammation : How and Why

    Author : Marie Hagbom; Lennart Svensson; Karl-Eric Mangusson; Ove Lundgren; Niklas Arnberg; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Rotavirus infections cause diarrhea and vomiting that can lead to severe dehydration. Despite extensive tissue damage and cell death, the inflammatory response is very limited. READ MORE

  5. 3. Tailored conjugates of N-acetylneuraminic acid and small molecules that block virus cell attachment and entry

    Author : Emil Johansson; Mikael Elofsson; Niklas Arnberg; Geert-Jan Boons; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; N-acetylneuraminic acid; Neu5Ac; sialic acid; multivalency; Coxsackievirus A24v CVA24v ; Human adenovirus D37; D36; D26; HAdV-D37; HAdV-D26; HAdV-D36 ; 4-O-alkyl Neu5Ac; cryo-EM; branched pleconaril probes; conjunctivitis; organisk kemi; Organic Chemistry;

    Abstract : Viruses are obligate intracellular parasites, unable to replicate without exploiting machinery andmaterials from host cells. Pandemics of viral diseases have had large impacts on human socieities and are continued threats to global health. READ MORE

  6. 4. Adenovirus-host interactions : implications for tropism and therapy

    Author : Annasara Lenman; Niklas Arnberg; Lennart Svensson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenoviridae; Amino Acids; Antiviral Agents; Epithelial Cells; Factor IX;

    Abstract : Human adenoviruses (HAdVs) are common viruses often associated withgastrointestinal, ocular and respiratory infections. They can infect a widevariety of cells, both dividing and non-dividing. HAdVs attach to and infecttarget cells through interactions with cellular receptors. READ MORE

  7. 5. Cellular receptors for species B adenoviruses

    Author : Marko Marttila; Niklas Arnberg; Göran Wadell; Tomas Bergström; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; CD46; CD80; CD86; Species B; Receptor; Internalization; Infection; Tropism; Virology; Virologi;

    Abstract : Adenoviruses belong to the most common human pathogens. The severity of infection varies greatly, from subclinical to lethal, depending on the virus type and immune status of the infected host. The 51 known human adenovirus serotypes are divided into six species (A-F) based on characteristics such as tropism. READ MORE