Search for dissertations about: "Nikolaos Venizelos"

Found 5 swedish dissertations containing the words Nikolaos Venizelos.

  2. 1. Biochemical and molecular studies of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency in cultured human fibroblasts

    Author : Nikolaos Venizelos; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency; trifunctional protein; cultured human fibroblasts.;

    Abstract : Inborn defects in mitochondrial B-oxidation of fatty acids are a group of diseases affecting humans usually early in life. At least 15 separate defects affecting the mitochondrial fatty acid B-oxidation in man have been identified . READ MORE

  4. 2. Amino acid transport and receptor binding properties in neuropsychiatric disorders using the fibroblast cell model

    Author : Jessica Johansson; Nikolaos Venizelos; Lars Oreland; Örebro universitet; []
    Keywords : Fibroblasts; Bipolar disorder; ADHD; Tyrosine; Tryptophan; Alanine; Transport; mAChRs; Biomedicin; Biomedicine;

    Abstract : Altered transport of the catecholamines and serotonin precursor amino acids tyrosine and tryptophan, might be one explanation for the dysfunctional neurotransmission implicated in the pathophysiology of bipolar disorder and Attention Deficit/Hyperactivity Disorder (ADHD). In previous studies, an altered amino acid transport has been found in schizophrenia and autism, when using the fibroblast cell model. READ MORE

  5. 3. Integration of functional genomics and data mining methodologies in the study of bipolar disorder and schizophrenia

    Author : Marianthi Logotheti; Nikolaos Venizelos; Fragiskos Kolisis; Nikos Stefanis; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bipolar Disorder; Schizophrenia; Fibroblasts; DNA Microarrays; Machine Learning; Functional Analysis; Gene Expression; Transcriptomics;

    Abstract : Bipolar disorder and schizophrenia are two severe psychiatric disorders characterized by a complex genetic basis, coupled to the influence of environmental factors. In this thesis, functional genomic analysis tools were used for the study of the underlying pathophysiology of these disorders, focusing on gene expression and function on a global scale with the application of high-throughput methods. READ MORE

  6. 4. Functional characterization of tyrosine and tryptophan transport in fibroblasts from healthy controls, patients with schizophrenia and bipolar disorder

    Author : Ravi Vumma; Nikolaos Venizelos; Tommy Lewander; Dimitrios Kyriakidis; Örebro universitet; []
    Keywords : Fibroblasts; Tyrosine; Tryptophan; LAT1; Schizophrenia; Bipolar disorder; MEDICINE; MEDICIN; Biomedicin; Biomedicine;

    Abstract : .... READ MORE

  7. 5. Functional Characterization of Tyrosine Transporters in fibroblast from Healthy Controls and Schizophrenic Patients

    Author : Ravi Vumma; Nikolaos Venizelos; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibroblasts; Schizophrenia; Precursor of Dopamine; Biological Transport; Active cellphysiology; Tyrosine and alanine transport; System-L; LAT1; LAT2; LAT3; LAT4; MEDICINE; MEDICIN; Internal medicine; Invärtesmedicin; Neurology; Neurologi; Neurology; Neurologi;

    Abstract : Cultured human fibroblasts offer an advantageous system to investigate the amino acid transport properties without confounding the affects of disease state and its treatment in many systemic psychiatric disorders. In previous studies, fibroblast cells have been used to investigate the tyrosine transport across plasma membranes in patients with schizophrenia and autism with out characterizing the particular amino acid transporters. READ MORE