Search for dissertations about: "Nitric oxide synthase NOS"

Showing result 1 - 5 of 71 swedish dissertations containing the words Nitric oxide synthase NOS.

2. 1. Nitric oxide in experimental sepsis

   Author : Peter Dahm; Anestesiologi och intensivvård; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intensive care; Nitric oxide; Sepsis; NO inhalation; Endotoxin; Acute lung injury; ARDS; Nitric oxide synthase; L-NMMA; L-NAME; Anestesiologi; Anaesthesiology; Pigs; intensivvård;

   Abstract : Nitric oxide (NO) is important in the control of blood pressure and organ perfusion. In septic shock, NO produced by inducible NO-synthase (NOS) has been claimed to mediate pathological vasodilation and cell injury, while NO produced by constitutive NOS may be protective in counteracting hypoperfusion and organ injury. READ MORE

4. 2. Inducible nitric oxide synthase in experimental urinary tract infection

   Author : Mirjana Poljakovic; Avdelningen för klinisk kemi och farmakologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urology; host defense; cell viability; nitrate; lipopolysaccaride; cytokines; sphingomyelinase; mitogen activator protein kinase; nitric oxide; nitrotyrosine; E. coli; cyclooxygenase; urinary tract infection; prostaglandins; urothelium; bladder; kidney; NADPH diaphorase histochemistry; nitric oxide synthase; vävnadskultur; histokemi; cytokemi; Histologi; tissue culture; histochemistry; cytochemistry; Histology; nefrologi; Urologi; nephrology; Infections; Infektioner;

   Abstract : Urinary tract infection (UTI) is among the most common bacterial infections in humans and the majority are caused by Escherichia coli (E. coli). Abundant evidence indicates that nitric oxide (NO) produced by the inducible NO synthase (iNOS) plays an important role in host defense against infection. READ MORE

5. 3. Novel Interventions in Cardiac Arrest : Targeted Temperature Management, Methylene Blue, S-PBN, Amiodarone, Milrinone and Esmolol,  Endothelin and Nitric Oxide In Porcine Resuscitation Models

   Author : Frank Zoerner; Fredrik Lennmyr; Cécile Martijn; Lars Wiklund; Sven Erik Gisvold; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; restoration of spontaneous circulation; ROSC; cardiopulmonary resuscitation; CPR; cardiac arrest; methylene blue; MB; S-PBN; mild therapeutic hypothermia; MTH; targeted temperature management; TTM; endothelin; ET-1; ECE-1; ETAR; ETBR; nitric oxide; NO; nitric oxide synthase; NOS; eNOS; iNOS; nNOS; porcine; amiodarone; hypovolemia; milrinone; vasopressin; esmolol; epinephrine; Anaesthesiology and Intensive Care; Anestesiologi och intensivvård; Medical Cell Biology; Medicinsk cellbiologi; Kardiologi; Cardiology;

   Abstract : It is a major clinical problem that survival rates after out-of-hospital cardiac arrest have not markedly improved during the last decades, despite extensive research and the introduction of new interventions. However, recent studies have demonstrated promising treatments such as targeted temperature management (TTM) and methylene blue (MB). READ MORE

6. 4. Islet constitutive nitric oxide synthase and nitric oxide production. Modulatory effects on insulin and glucagon secretion

   Author : Björn Åkesson; Allmänmedicin och klinisk epidemiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; Pharmacological sciences; mouse; carbachol; muscarinic agonist; cyclic nucleotides; calcium-fluxes; NOS-inhibitors; in vitro and in vivo; insulin and glucagon secretion; Nitric oxide NO ; constitutive nitric oxide synthase cNOS ; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Abstract : The aim of this thesis was to elucidate the role of nitric oxide (NO) in the transduction signalling of insulin and glucagon release by stimulating or inhibiting islet endogenous NO-production as well as by using NO donors. Insulin release stimulated by L-arginine, the substrate for constitutive NO-synthase (cNOS)-catalyzed NO-production, was increased by the selective NOS-inhibitor NG-nitro-L-arginine methyl ester (L-NAME) and suppressed by the intracellular NO donor hydroxylamine. READ MORE

7. 5. Nitric oxide production by the intestinal mucosa during hypoperfusion

   Author : Johan Snygg; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nitric oxide; nitric oxide synthase; intestinal epithelium; hemorrhagic shock; cardiac tamponade; septic shock; lower body negative pressure; splanchnic circulation; substrate; laser Doppler;

   Abstract : The present thesis is based on the concept that gastrointestinal blood hypoperfusion is a common phenomenon associated with critical illness. Furthermore, the development of the multiple organ dysfunction syndrome (MODS) is proposed to be initiated by gastrointestinal mucosal barrier dysfunction, allowing intestinal luminal contents to penetrate into the tissue and activate a systemic inflammatory response. READ MORE