Search for dissertations about: "Nociceptin"
Showing result 1 - 5 of 14 swedish dissertations containing the word Nociceptin.
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1. Biological membrane interfaces involved in diseases : a biophysical study
Abstract : Interactions between peptides and biological lipid membranes play a crucial role in many cellular processes such as in the mechanism behind Alzheimer’s disease where amyloid-beta peptide (Abeta)is thought to be a key component. The initial step of binding between a surface active peptide and its target membrane or membrane receptor can involve a non specific electrostatic association where positively charged amino acid residues and a negatively charged membrane surface interact. READ MORE
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2. Neuropeptides and spinal antinociception : studies on galanin, nociceptin and endomorphin
Abstract : Nociception and/or the sensation of pain is essential for the survival of the organism. Just as important are the antinociceptive mechanisms that reduce the nociceptive input and perceived pain. Without such mechanisms, it would be impossible to turn ones focus away from even the most minor painful stimulus. READ MORE
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3. PACAP and orphanin FQ/nociceptin -Distribution, importance and regulation in sensory neurons and spinal cord
Abstract : Neuropeptide expression in the nervous system is abundant and plastic, and an altered expression after injury is an example of a functional response, helping the neuron to cope with adverse changes, and involves effects on differentiation, synthesis, repair/regeneration, survival, and modulation of signal transmission. I have investigated the distribution/expression of the neuropeptides, orphanin FQ/nociceptin (OFQ/N) and pituitary adenylate cyclase activating polypeptide (PACAP), under normal conditions, in response to nerve injuries, and also studied sensory responses in mice deficient for the PAC1 receptor (PAC1-/-). READ MORE
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4. Stress, Drugs and Neuroscience : Neurobiological Effects of Social Stressors and Drug Exposure in Young and Adolescent Rats
Abstract : Experiences early in life or during adolescence modulate neuronal networks in the immature brain and consequently lay the foundation for future susceptibility or resilience towards psychiatric disorders. The objective in this thesis is to understand, in part, how the surrounding environment shapes the brain of a young individual. READ MORE
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5. Endogenous Opioids and Voluntary Ethanol Drinking : Consequences of Postnatal Environmental Influences in Rats
Abstract : Genetic and environmental factors interact to determine the individual vulnerability to develop ethanol dependence. The neurobiological mechanisms underlying these processes are not fully understood. Endogenous opioid peptides have been suggested to contribute. READ MORE