Search for dissertations about: "Nociception"

Showing result 1 - 5 of 48 swedish dissertations containing the word Nociception.

  1. 1. Bioactive Lipids in Nociception

    University dissertation from Clinical Chemistry and Pharmacology, Dept of Laboratory Medicine

    Author : Anna Ermund; Lund University.; Lunds universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cannabinoids; Anandamide; AM404; 2-Arachidonoylglycerol; Acetaminophen; Cyclooxygenase; Nocicieption; TRPV1;

    Abstract : This thesis focuses on bioactive lipids as (1) metabolites of the widely used antipyretic and analgesic drug acetaminophen and (2) activators of the ion channel TRPV1, an important downstream target for inflammatory mediators, in the phospholipase C (PLC)/TRPV1 signaling pathway. Evidence is presented for a fatty acid amide hydrolase (FAAH)-dependent fatty acid conjugation of p-aminophenol, a known acetaminophen metabolite, to form the potent TRPV1 activator AM404 in the central nervous system. READ MORE

  2. 2. Spotting pain in the brain. Towards a useful animal model of pain

    University dissertation from Division of Neuroscience, Department of Experimental Medical Sciences, Lund University

    Author : Tanja Jensen; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; analgesics; freely moving rat; microelectrode; Nociception; Primary somatosensory cortex; Sedatives;

    Abstract : Current models of pain in conscious animals usually scores nocifensive responses. However, it is still unclear to what extent these responses are related to, for instance, the sensory discriminative or affective aspects of pain. READ MORE

  3. 3. Acetylcholine in Spinal Pain Modulation An in vivo Study in the Rat

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Klas Abelson; Uppsala universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Laboratory animals; Pain; Nociception; Antinociception; Acetylcholine; Muscarinic; Nicotinic; Spinal cord; Microdialysis; Försöksdjursvetenskap; MEDICINE Physiology and pharmacology Physiology Laboratory animal science; MEDICIN Fysiologi och farmakologi Fysiologi Försöksdjursvetenskap;

    Abstract : The spinal cord is an important component in the processing and modulation of painful stimuli. Nerve signals from the periphery are relayed and further conducted to the brain (nociception) in the spinal cord, and the most essential modulation of painful information (antinociception) occurs here. READ MORE

  4. 4. Effects of repetitive work on proprioception and of stretching on sensory mechanisms implications for work-related neuromuscular disorders

    University dissertation from Umeå : Kirurgisk och perioperativ vetenskap

    Author : Martin Björklund; Högskolan i Gävle.; Umeå universitet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Repetitive motions; Muscle fatigue; Proprioception; Muscle stretching; Workrelated musculoskeletal disorders; Nociception; Ergonomics; MEDICINE Dermatology and venerology; clinical genetics; internal medicine; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin; medicin; Medicine; Medicine; Work-related musculoskeletal disorders; Medicin;

    Abstract : The aims of the thesis were (i) to investigate the impact of repetitive low-intensity work exposure on proprioception and (ii) to examine effects of muscle stretching (especially sensory effects and effects on muscle nociception) and to relate its application to the prevention, alleviation and/or treatment of work-related neuromuscular disorders. The effects of low-intensity repetitive work on the shoulder proprioception were tested in healthy subjects. READ MORE

  5. 5. Activation and Regulation of TRPV1 : Studies in Recombinant Human Neuroblastoma TRPV1-SHSY5Y Cells

    University dissertation from Stockholm : Department of Neurochemistry, Stockholm University

    Author : Johanna EL Andaloussi-Lilja; Stockholms universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nociception; neurotrophic factors; eye irritation; stable transfection; Ca2 ; MEDICINE Chemistry Neurochemistry; MEDICIN Kemi Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : TRPV1 is a transmembrane non-selective cation channel with preference for Ca2+. The receptor is primarily localised on dorsal root ganglion neurons and is activated by numerous endogenous and exogenous potentially irritating ligands eliciting pain. READ MORE