Search for dissertations about: "Nonsense-mediated decay"

Showing result 1 - 5 of 6 swedish dissertations containing the words Nonsense-mediated decay.

  2. 1. Simplified Nonsense: New Methods for Interrogating NMD

    Author : Hanna Alalam; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mRNA degradation; metabolic labeling; nonsense-mediated decay; Major protease; SARS-CoV-2;

    Abstract : Nonsense mediated decay (NMD) is a pathway that regulates RNA turnover. Since its discovery, this pathway has been implicated in a variety of cellular processes ranging from differentiation to the restriction of viral replication. READ MORE

  4. 2. Molecular Mechanisms of Frontotemporal Lobar Degeneration

    Author : Lena Skoglund; Anna Glaser; Martin Ingelsson; Lars Lannfelt; Stuart Pickering-Brown; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Frontotemporal lobar degeneration; Frontotemporal dementia; Tau; Progranulin; Alternative splicing; Nonsense-mediated decay; Haploinsufficiency;

    Abstract : The aim of this thesis was to identify genetic factors involved in frontotemporal lobar degeneration (FTLD), a neurodegenerative disorder clinically characterised by a progressive change in personality, behaviour and language. FTLD is a genetically complex disorder and a positive family history is found in up to 40% of the cases. READ MORE

  5. 3. The regulation of incorrect splicing of ISCU in hereditary myopathy with lactic acidosis

    Author : Denise F. R. Rawcliffe; Monica Holmberg; Helena Edlund; Diana Baralle; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HML; ISCU; Splicing; SRSF3; PTBP1; RBM39; MBNL1; medicinsk genetik; Medical Genetics;

    Abstract : Patients suffering from hereditary myopathy with lactic acidosis (HML) can be found in the northern Swedish counties of Ångermanland and Västerbotten. HML is a rare autosomal recessive disease where patients display a low tolerance to exercise at an early age. READ MORE

  6. 4. Regulation of pre-mRNA splicing and mRNA degradation in Saccharomyces cerevisiae

    Author : Yang Zhou; Marcus Johansson; Anders Byström; Marie Öhman; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NMD; RES complex; pre-mRNA splicing; magnesium homeostasis;

    Abstract : Messenger RNAs are transcribed and co-transcriptionally processed in the nucleus, and transported to the cytoplasm. In the cytoplasm, mRNAs serve as the template for protein synthesis and are eventually degraded. The removal of intron sequences from a precursor mRNA is termed splicing and is carried out by the dynamic spliceosome. READ MORE

  7. 5. Biogenesis of messenger and ribosomal RNPs in the eukaryotic cell

    Author : Petra Björk; Juan Valcárcel; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Physical Biology; fysikalisk biologi;

    Abstract : In eukaryotic cells, gene expression involves multi-step processes in the nucleus and the cytoplasm. The different processes engage specific RNA-protein complexes, RNPs. Upon activation of most, if not all genes, a precursor RNA molecule is synthesized that has to be extensively processed and modified. READ MORE