Search for dissertations about: "Nonsense"
Showing result 1 - 5 of 49 swedish dissertations containing the word Nonsense.
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1. Simplified Nonsense: New Methods for Interrogating NMD
Abstract : Nonsense mediated decay (NMD) is a pathway that regulates RNA turnover. Since its discovery, this pathway has been implicated in a variety of cellular processes ranging from differentiation to the restriction of viral replication. READ MORE
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2. Pharmacological targeting of nonsense mutant TP53 and PTEN in cancer
Abstract : The TP53 tumor suppressor gene encodes p53 and is inactivated by mutations in around half of all human tumors. Approximately 11% of TP53 mutations are nonsense mutations, resulting in the premature termination of translation and the production of truncated and non-functional p53 proteins. READ MORE
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3. Making sense from nonsense and missense : pharmacological rescue of mutant tumor suppressor p53
Abstract : A large fraction of human tumors carry inactivating mutations in the TP53 tumor suppressor gene. Approximately 75% of these mutations are missense mutations and around 10% are nonsense mutations. TP53 inactivation allows evasion of cell death and rapid tumor progression. READ MORE
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4. Molecular Mechanisms of Frontotemporal Lobar Degeneration
Abstract : The aim of this thesis was to identify genetic factors involved in frontotemporal lobar degeneration (FTLD), a neurodegenerative disorder clinically characterised by a progressive change in personality, behaviour and language. FTLD is a genetically complex disorder and a positive family history is found in up to 40% of the cases. READ MORE
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5. Translational readthrough of nonsense mutant TP53, RB1 and PTEN tumor suppressor genes as a strategy for novel cancer therapy
Abstract : A nonsense mutation causes a premature termination codon in the coding sequence of an mRNA. This leads to termination of translation and release of a truncated and in most cases non-functional protein. READ MORE
