Search for dissertations about: "Novel Method"

Showing result 1 - 5 of 2329 swedish dissertations containing the words Novel Method.

  2. 1. Targeted analysis of bioactive steroids and oxycholesterols : Method development and application

    Author : Neil de Kock; Jonas Bergquist; Ulf Diczfalusy; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Steroids; Oxycholesterols; Supercritical Fluid Chromatography; Mass Spectrometry; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Abstract : Peripheral steroids and oxycholesterols are important lipid compounds controlling various functions in the human body. Steroid analysis of biological samples is routinely employed in the clinical environment as an essential source of information on endocrine and metabolic disorders. READ MORE

  4. 2. A Novel Immersed-Boundary Method for Multiple Moving and Interacting Bodies

    Author : Andreas Mark; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; fluid-structure interaction; DNS; immersed-boundary method;

    Abstract : This thesis describes the development, implementation and validation of an implicit, second order accurate, finite-volume and instationary immersed-boundary method for simulating the detailed flow around multiple arbitrary moving and interacting bodies. The potential for flows including moving bodies or boundaries, such as multiphase flows still has to be fully realized. READ MORE

  5. 3. Drug Repositioning for Cancer Treatment : Novel Candidate Identification Strategies

    Author : Madiha Nazir; Mårten Fryknäs; Sigurd Vitols; Uppsala universitet; []
    Keywords : cancer treatment; drug repositioning; Phosphodiesterase 3A PDE3A ; apoptosis; combination screening;

    Abstract : Regardless of the enormous investments in cancer research and drug development, the proportion of approved drugs in oncology is low compared to other indications, and new avenues are needed. One attractive approach in this regard is drug repositioning where new uses outside the scope of the original medical indications for existing drugs are identified. READ MORE

  6. 4. Transmission Electron Microscopy of Graphene and Hydrated Biomaterial Nanostructures : Novel Techniques and Analysis

    Author : Sultan Akhtar; Klaus Leifer; Hilborn Jöns; Stefano Rubino; Marco Cantoni; Uppsala universitet; []
    Keywords : Graphene flakes; magnetic beads DNA coils; hydrated biomaterials; transmission electron microscopy; focused ion beam scanning electron microscopy; bright-field dark-field imaging; high resolution imaging; electron diffraction and cryogenic temperatures; Materialvetenskap; Materials Science;

    Abstract : Transmission Electron Microscopy (TEM) on light element materials and soft matters is problematic due to electron irradiation damage and low contrast. In this doctoral thesis techniques were developed to address some of those issues and successfully characterize these materials at high resolution. READ MORE

  7. 5. Ribosomal translocation in real time : Method development to Applications

    Author : Chang-il Kim; Suparna Sanyal; Martin Ott; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ribosome; EF-G; pyrene mRNA; aminoglycoside; ribosomal protein; GTP hydrolysis; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : Translational elongation is the process in which the ribosome adds one amino acid at a time to the nascent peptide chain. As the ribosome elongates the peptide chain by 14 - 20 amino acids per second and performs hundreds of such cycles per protein, ‘elongation’ is one of the most crucial steps in translation. READ MORE