Search for dissertations about: "Novel drug resistance in cancer"
Showing result 1 - 5 of 68 swedish dissertations containing the words Novel drug resistance in cancer.
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1. Circumventing drug resistance : Studies exploring the expediency of a total cell kill chemoresistance assay
Abstract : Cellular resistance to anti-cancer drugs is considered to be the major cause of treatment failure in clinical practice. The present studies have therefore focused on ways to circumvent resistance as evaluated by an in vitro chemoresistance assay. READ MORE
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2. ASNA1 and cisplatin resistance : studies in C. elegans and in human tumor cells
Abstract : Platinum based chemotherapy is widely used to treat cancer. Cisplatin (diamminedichloroplatinum) combination treatments provide cure for metastatic testicular cancer and prolong survival for patients suffering from ovarian, head and neck, bladder and non small cell lung cancer. READ MORE
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3. Modelling the evolution of treatment-induced resistance in Ph+ leukaemias
Abstract : Targeted therapies are a mainstay of modern cancer treatments. Rather than harming rapidly dividing cells in general, targeted therapies work by directly interfering with oncogenic molecular pathways present in a tumour. Consequently, a targeted therapy typically has less severe side effects. READ MORE
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4. Signaling pathways and novel genetic factors involved in modulation of cisplatin response in C. elegans
Abstract : Cancer is a major cause of mortality throughout the world. Despite the effort of the scientific community, plenty remains to understand about the biology or genetics of cancer. In solid tumors often as many as 90-99% of all cells are non-dividing. READ MORE
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5. The role of phosphatidylinositol 4-phosphate 5-kinase type І alpha (PIP5K1α) and utility of its inhibitor for targeting metastatic cancer
Abstract : Prostate cancer (PCa) is the most common cause of cancer-related death in men after lung cancer. Annually, more than 9000 new cases are diagnosed in Sweden and 2500 of them die each year. Metastatic prostate cancer can be treated with castration. READ MORE