Search for dissertations about: "Nuclear Localization Signals"

Showing result 1 - 5 of 19 swedish dissertations containing the words Nuclear Localization Signals.

  2. 1. Digital Image Analysis of Cells : Applications in 2D, 3D and Time

    Author : Amalka Pinidiyaarachchi; Carolina Wählby; Ewert Bengtsson; Arvid Lundervold; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Digital image analysis; microscopy; fluorescent staining; watershed segmentation; sub-cellular localization; point-like signals; wavelets; cell confluence; cytology; color spaces.; Image analysis; Bildanalys;

    Abstract : Light microscopes are essential research tools in biology and medicine. Cell and tissue staining methods have improved immensely over the years and microscopes are now equipped with digital image acquisition capabilities. The image data produced require development of specialized analysis methods. READ MORE

  4. 2. Modulation of nuclear receptor function by interacting proteins

    Author : Waffa Osman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nuclear receptors are a family of transcription factors involved in many biological processes. They represent key potentials as therapeutic targets for several clinical conditions such as diabetes, obesity, cardiovascular disease and cancer, because their activity is modulated by small molecules. READ MORE

  5. 3. Embryonic Stem Cells: Differentiation into Insulin Producing Cells and Elimination of Damaged Proteins

    Author : Gabriella Brolén; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; oxidatively damaged proteins; diabetes; carbonyl; C-peptide; Medicine human and vertebrates ; insulin; human embryonic stem cell; 20S proteasome; AGE; Pdx1; proinsulin;

    Abstract : This thesis includes two different parts: One focusing on how to induce human embryonic stem cells (hESCs) to differentiate into insulin producing cells by following the normal pancreatic development pathway. These cells have then the potential to be an unlimited source for diabetes regenerative medicine. READ MORE

  6. 4. Computational Methods for Image-Based Spatial Transcriptomics

    Author : Axel Andersson; Carolina Wählby; Anna Klemm; Filip Malmberg; Karl Åström; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Spatial omics; Spatial transcriptomics; Spatial biology; In Situ Sequencing; Visualization; Spatial statistics; Fluorescence microscopy; Computerized Image Processing; Datoriserad bildbehandling;

    Abstract : Why does cancer develop, spread, grow, and lead to mortality? To answer these questions, one must study the fundamental building blocks of all living organisms — cells. Like a well-calibrated manufacturing unit, cells follow precise instructions by gene expression to initiate the synthesis of proteins, the workforces that drive all living biochemical processes. READ MORE

  7. 5. Towards smart antisense and antigene therapeutics : design and synthesis of novel oligonucleotide based bioconjugates

    Author : Martina Jezowska-Herrera; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The use of nucleic acid technology has been of great importance in life science research. In several clinical trials patients with genetic disease are treated with help of innovations based on oligonucleotide therapy. The use of it is unfortunately limited in efficacy due to e.g. READ MORE