Search for dissertations about: "Nuclear hormone receptor"

Showing result 1 - 5 of 80 swedish dissertations containing the words Nuclear hormone receptor.

  2. 1. Enzymatic Regulation of Steroidogenesis and Nuclear Receptor Activation : Special Focus on Vitamin D and Sex Hormones

    Author : Johan Lundqvist; Kjell Wikvall; Maria Norlin; Magnus Ingelman-Sundberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adrenal steroidogenesis; CYP7B1; vitamin D; calcitriol; enzymatic regulation; transcriptional regulation; CYP21A2; aromatase; sex hormone; estrogen; androgen; nuclear receptor; Pharmaceutical biochemistry; Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : Enzyme-catalyzed reactions are important to regulate steroidogenesis and nuclear receptor activation. The present investigation examines the role of steroid metabolism catalyzed by CYP7B1 for regulation of hormone receptor activation and the effects of vitamin D on enzymatic regulation of steroidogenesis. READ MORE

  4. 2. Functional studies on the nuclear receptor Nurr1

    Author : Mariette Nordzell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The nuclear receptor (NR) superfamily comprises the largest family of ligand-activated transcription factors in eukaryotes, and it plays critical roles in many aspects of vertebrate development and physiology. The NR family is well conserved throughout evolution, and is found in organisms as diverse as nematodes, flies and mammals. READ MORE

  5. 3. Nuclear hormone receptors studied by molecular dynamics computer simulations

    Author : Peter Carlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Nuclear hormone receptor; glucocorticoid; molecular dynamics; simulation; ligand; coactivator; protein; solvation;

    Abstract : Nuclear hormone receptors form a super family of homologous transcription factors. The liganddependent nuclear receptors are important drug targets controlling metabolic and inflammatory disorders, amongst others. READ MORE

  6. 4. Gene regulation by nuclear hormone receptors in vivo

    Author : Anethe Mansén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The nuclear hormone receptor superfamily contains 49 different members, including those for thyroid hormone, TR? and TR?. These receptors are ligand-modulated transcription factors that activate or repress gene activity. The TR? gene encodes two main splice variants, TR?1 and TR?2. READ MORE

  7. 5. Thyroid hormone receptor expression in cardiovascular disease and pharmacology

    Author : Shiva Shahrara; Karolinska Institutet; Karolinska Institutet; []
    Keywords : TR mRNA; amiodarone; propranolol; heart rate; Quantitative RT-PCR; Western blot; Northern blot; mRNA and protein distribution; chronic valvular disease; Mated cardiomyopathy; AT- I cardiomyocytes; mouse myocardium;

    Abstract : The heart is a major target organ for thyroid hormone actions. Thyroid hormone exerts effects on the myocardium, which are mediated by specific nuclear receptors. The thyroid hormone receptors (TR) are members of the steroid hormone receptor superfamily. READ MORE