Search for dissertations about: "Nucleotidases"

Found 4 swedish dissertations containing the word Nucleotidases.

  1. 1. Structural Studies of Human 5'-Nucleotidases

    Author : Karin Walldén; Pär Nordlund; Norbert Sträter; Stockholms universitet; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Nucleotidases; nucleotide; nucleoside; nucleoside analogue; Structural biochemistry; Strukturbiokemi; biokemi; Biochemistry;

    Abstract : 5’-Nucleotidases (5’NTs) are catabolic enzymes of the nucleotide metabolism. They catalyze dephosphorylation of deoxyribo- and ribonucleoside monophosphates and constitute an important control point in the regulation of intracellular nucleotide pools for the maintenance of correct DNA and RNA synthesis. READ MORE

  2. 2. The role of 5 -nucleotidases and deoxynucleoside kinases in responses to nucleoside analogues

    Author : Saeedeh Mirzaee; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The efficacy of nucleoside analogues (NAs) in treating several hematological malignancies, solid tumors and viral infections is limited primarily by side-effects and the development of drug resistance. The aims of the present thesis were to elucidate mechanism(s) involved in tissue-specific toxicity associated with NA therapy, as well as the mechanisms underlying resistance to these drugs. READ MORE

  3. 3. Molecular regulators of glucose and lipid metabolism in skeletal muscle

    Author : Sameer S Kulkarni; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Skeletal muscle is a primary site of insulin action and insulin-stimulated glucose transport and occupies a center stage in maintaining whole body glucose and lipid homeostasis. Another key feature of a healthy skeletal muscle is its ability to switch between utilization of lipids and glucose as fuel in response to feeding or fasting respectively. READ MORE

  4. 4. Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs

    Author : Xin Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy. Cancer drug resistance includes two broad categories: intrinsic and acquired. READ MORE