Search for dissertations about: "Nudix hydrolase"

Showing result 1 - 5 of 7 swedish dissertations containing the words Nudix hydrolase.

  2. 1. Diversity and persistence of Helicobacter pylori

    Author : Annelie Lundin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Helicobacter pylori; genomic diversity; cag pathogenicity island; Nudix hydrolase;

    Abstract : Helicobacter pylori is an exceptionally diverse bacterial species, and every infected individual harbors a unique strain, apart from the strain concordance found in some families. The infection is usually acquired during childhood and once established, persists for life unless treated with antibiotics. READ MORE

  4. 2. Roles of NUDT5 and NUDT15 beyond oxidized nucleotide sanitation and their potential as therapeutic targets

    Author : Nicholas Carl Kristoffer Valerie; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The nucleotide precursor pool is readily susceptible to numerous sources of modification and damage, including alkylation, deamination and oxidation/nitrosylation, among others; most of which have deleterious effects on nucleic acid integrity and cellular fitness. In addition to DNA repair mechanisms, these metabolic byproducts are kept in check by so-called sanitation or “housekeeping” enzymes, chief among them the NUDIX hydrolase superfamily. READ MORE

  5. 3. Functional characterization of a peroxisomal acyltransferase gene family

    Author : Sarah-Jayne Reilly; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Peroxisomes are cell organelles that play an important role in the metabolism of a variety of lipids including very long chain fatty acids, dicarboxylic acids, bile acids, and xenobiotic carboxylic acids. The metabolism of lipids in peroxisomes requires the concerted efforts of many different enzymes, which includes members of the type I acyl-CoA thioesterase/acyltransferase protein family and the nudix hydrolases. READ MORE

  6. 4. The mammalian peroxisome : ‛its function and distribution’

    Author : Veronika Tillander; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Peroxisomes are essential organelles for normal cell functions in all organisms from yeast to human. Their important contribution in different metabolic pathways is clearly visible by the severe phenotypes seen in the majority of peroxisomal diseases, where the symptoms often leads to an early death. READ MORE

  7. 5. Targeting DNA repair pathways for cancer therapy

    Author : Saeed Eshtad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Accumulation of genomic mutations is the consequence of failure in DNA repair as well as increased exposure to endogenous/environmental mutagens. DNA repair pathways safeguard the human genome from such mutagens, and thereby suppress the multi-step process of carcinogenesis. READ MORE