Search for dissertations about: "O-glycans"

Showing result 1 - 5 of 10 swedish dissertations containing the word O-glycans.

  1. 1. Recombinant mucin-type proteins as tools for studies on the interactions between Helicobacter pylori and its carbohydrate receptors

    Author : Yolanda H. Mthembu; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; O-glycans; mucins; glycosyltransferases; Helicobacter pylori; microbial adhesion;

    Abstract : Glycan-protein interactions are important in pathogen adhesion and infections. H. pylori has adhesins which enables it to bind to glycans on the gastric mucosa and, in the long run, cause gastric cancer. The reported current antibiotic regimen used in the treatment to eradicate H. READ MORE

  2. 2. Studies on the biosynthesis of ABH and Lewis epitopes on O-glycans

    Author : Jonas Löfling; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Fucose; Lewis antigen; Blood group ABH; biosynthesis;

    Abstract : ABH and Lewis antigens are carbohydrate epitopes (glycans) found on a wide variety of cell surfaces. They are involved in many biological processes, e.g transplantation rejection, bacterial and viral adhesion, cell-cell communication and metastasis. The in vivo synthesis of glycans is mediated by glycosyltransferases (GTs). READ MORE

  3. 3. Pichia pastoris as a platform for the production of therapeutic glycoproteins

    Author : Magnus Sjöblom; Luleå tekniska universitet; []

    Abstract : Recombinant protein therapeutics is a growing market within the human medical biotechnology industry. The majority of all approved biopharmaceuticals are protein based and includes for example blood factors, anticoagulants, hormones, vaccine and monoclonal antibodies. READ MORE

  4. 4. Targeting the human glycoproteome: new enrichment protocols and mass spectrometric analyses reveal unique and novel glycosylation sites

    Author : Adnan Halim; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Glycobiology; Glycoproteomics; Mass Spectrometry;

    Abstract : Glycosylation is one of the most common and structurally diverse posttranslational modifications of proteins. Given that protein glycosylation is involved in various cellular processes, the characterization of site-specific N- and O-linked glycosylations is becoming increasingly important. However, current mass spectrometry-based technologies, i.e. READ MORE

  5. 5. A New Look into Protein C Inhibitor : Posttranslational Modifications and their Functions

    Author : Wei Sun; Sophia Schedin Weiss; Hakon Leffler; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protein C inhibitor; posttranslational modifications; N-glycan; O-glycan; mass spectrometry; factor Xa; thrombin; prostate specific antigen; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Abstract : The influences of posttranslational modifications on the functions of the versatile serpin protein C inhibitor (PCI) were studied. PCI is a serine protease inhibitor that is expressed in many tissues and secreted to various fluids in human, including blood plasma, seminal plasma, and urine. READ MORE