Search for dissertations about: "O-linked glycosylation"
Showing result 6 - 10 of 13 swedish dissertations containing the words O-linked glycosylation.
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6. Development and Evaluation of Tools to Explore Posttranslational HexNAc-Tyrosine and Mucin-Type O-Glycosylation
Abstract : Glycosylation is the most abundant form of post-translational modification (PTM). Recently, O-glycosylation attracted much attention in the glycoproteomic field due to its association with various diseases, such as pathogenic infections and cancer. READ MORE
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7. Free oligosaccharides and glycosylation of bile salt-stimulated lipase in human milk
Abstract : Bile salt-stimulated lipase (BSSL) is a glycosylated protein present in milk at a concentration of 100-200 mg/L. It is an enzyme important for fat digestion in the newborn infant. The protein backbone contains one possible site for N-glyeosylation and several sites for 0-glyeosylation. READ MORE
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8. Targeting the human glycoproteome: new enrichment protocols and mass spectrometric analyses reveal unique and novel glycosylation sites
Abstract : Glycosylation is one of the most common and structurally diverse posttranslational modifications of proteins. Given that protein glycosylation is involved in various cellular processes, the characterization of site-specific N- and O-linked glycosylations is becoming increasingly important. However, current mass spectrometry-based technologies, i.e. READ MORE
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9. Studies on O-glycosylation of mucin-type proteins and their binding to antibodies, bacterial toxins and viral receptors
Abstract : Carbohydrates are ubiquitous on the surface of all cells in mammals where they are involved in interactions with the surroundings (extracellular matrix), other cells (including self and non-self) and microbes (bacteria and virus). Carbohydrate-protein interactions in nature are often mediated via multivalent binding where the combined strength of multiple receptor- ligand interactions results in a binding that is highly specific and strong. READ MORE
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10. The role of polysaccharide modifications during Drosophila development
Abstract : Glucosides attached to proteins and lipids have been shown to modulate the activity of signal transduction pathways regulating growth and patterning processes during animal development. In particular, O-linked glycans such as glycosaminoglycans (GAGs) have been implicated in modulation of growth factor signaling pathways. READ MORE