Search for dissertations about: "O-linked glycosylation"

Showing result 6 - 10 of 13 swedish dissertations containing the words O-linked glycosylation.

  2. 6. Development and Evaluation of Tools to Explore Posttranslational HexNAc-Tyrosine and Mucin-Type O-Glycosylation

    Author : Sandra Behren; Ulrika Westerlind; Mikael Elofsson; Carmen Galan; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Glycopeptides; mucins; mucin type-O-glycosylation; microarrays; tyrosine-O-HexNAcylation; lectins; MUC1 cancer vaccines; TcdA; LecB; galectins; LacdiNAc; antibodies; biologisk kemi; biological chemistry; Biorganic Chemistry; bioorganisk kemi; organisk kemi; Organic Chemistry;

    Abstract : Glycosylation is the most abundant form of post-translational modification (PTM). Recently, O-glycosylation attracted much attention in the glycoproteomic field due to its association with various diseases, such as pathogenic infections and cancer. READ MORE

  4. 7. Free oligosaccharides and glycosylation of bile salt-stimulated lipase in human milk

    Author : Eva Landberg; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Bile salt-stimulated lipase (BSSL) is a glycosylated protein present in milk at a concentration of 100-200 mg/L. It is an enzyme important for fat digestion in the newborn infant. The protein backbone contains one possible site for N-glyeosylation and several sites for 0-glyeosylation. READ MORE

  5. 8. Targeting the human glycoproteome: new enrichment protocols and mass spectrometric analyses reveal unique and novel glycosylation sites

    Author : Adnan Halim; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glycobiology; Glycoproteomics; Mass Spectrometry;

    Abstract : Glycosylation is one of the most common and structurally diverse posttranslational modifications of proteins. Given that protein glycosylation is involved in various cellular processes, the characterization of site-specific N- and O-linked glycosylations is becoming increasingly important. However, current mass spectrometry-based technologies, i.e. READ MORE

  6. 9. Studies on O-glycosylation of mucin-type proteins and their binding to antibodies, bacterial toxins and viral receptors

    Author : Stefan Gaunitz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Carbohydrates are ubiquitous on the surface of all cells in mammals where they are involved in interactions with the surroundings (extracellular matrix), other cells (including self and non-self) and microbes (bacteria and virus). Carbohydrate-protein interactions in nature are often mediated via multivalent binding where the combined strength of multiple receptor- ligand interactions results in a binding that is highly specific and strong. READ MORE

  7. 10. The role of polysaccharide modifications during Drosophila development

    Author : Florian Lüders; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ontogeni; growth animal ; embryologi; Development biology; Decapentaplegic; Hedgehog; Wingless; Sulfation; Pipe; Glycosaminoglycan; Glycosyltransferase; ontogeny; embryology; Utvecklingsbiologi;

    Abstract : Glucosides attached to proteins and lipids have been shown to modulate the activity of signal transduction pathways regulating growth and patterning processes during animal development. In particular, O-linked glycans such as glycosaminoglycans (GAGs) have been implicated in modulation of growth factor signaling pathways. READ MORE