Search for dissertations about: "O6-methylguanine DNA methyltransferase"

Showing result 1 - 5 of 10 swedish dissertations containing the words O6-methylguanine DNA methyltransferase.

  2. 1. O6-methylguanine-DNA-methyltransferase and DNA mismatch repair in relation to drug resistance in malignant melanoma

    Author : Shuhua Ma; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Melanoma; chemotherapy; dacarbazine; drug resistance; O6-methylguanineDNAmethyltransferase; DNA mismatch repair;

    Abstract : Although the survival rate of patients with malignant melanoma has improved, treatment of the disease poses large problems since disseminated melanoma frequently shows primary resistance to chemotherapy. Resistance to chemotherapy is thus a major clinical problem and a cause of failure in the treatment of metastatic malignant melanoma. READ MORE

  4. 2. Pancreatic Endocrine Tumors and GIST - Clinical Markers, Epidemiology and Treatment

    Author : Sara Ekeblad; Britt Skogseid; Peter Stålberg; Barbro Eriksson; Rajesh Thakker; Uppsala universitet; []
    Keywords : Medicine; Pancreatic endocrine tumor; Gastrointestinal stromal tumor; Neuroendocrine; Multiple endocrine neoplasia type 1; Prognostic factors; Temozolomide; TNM staging; O6-methylguanine DNA methyltransferase; Growth hormone secretagogue receptor; Ghrelin; Medicin;

    Abstract : Pancreatic endocrine tumors and gastrointestinal stromal tumors are rare. Evidence regarding prognostic factors, and in the former also treatment, is scarce. We evaluated the survival and prognostic factors in a consecutive series of 324 patients with pancreatic endocrine tumors treated at a single institution. READ MORE

  5. 3. Risk and prognostic factors for malignant glioma

    Author : Sara Sjöström; Beatrice S Melin; Ulrika Andersson; Monika Hegi; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; Glioblastoma; Risk; Outcome; EGR; EGFR; VEGF; VEGFR; DNA repair; virus; Oncology; Onkologi; onkologi; Oncology;

    Abstract : Background: Glioblastoma is the most common and aggressive type of glioma and associated with poor prognosis. Apart from ionizing radiation and some rare genetic disorders, few aetiological factors have been identified for primary brain tumours. READ MORE

  6. 4. Studies of resistance factors against chloroethylnitrosourea drugs in malignant tumor cells

    Author : Suzanne Egyházi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : drug resistance 1; 3-bis 2-chloroethyl -1-nitrosourea O6-methylguanine-DNA methyltransferase glutathione transferase glutathione lung cancer melanoma;

    Abstract : Drug resistance is a major clinical problem in the chemotherapy of tumor diseases and the identification of factors that make tumor cells resistant to drug treatment is therefore of crucial importance. We have investigated a possible involvement of O6-methylguanine-DNA methyltransferase (MGMT), glutathione transferase (GST) and glutathione (GSH) in the resistance to 1,3- bis(2-chloroethyl)-1-nitrosourea (BCNU) in two human lung cancer cell lines. READ MORE

  7. 5. Quantum Chemical Modeling of Enzymatic Methyl Transfer Reactions

    Author : Polina Georgieva; Fahmi Himo; Nino Russo; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; reaction mechanism; Theoretical chemistry; Teoretisk kemi;

    Abstract : In this thesis, quantum chemistry, in particular the B3LYP density functional method, is used to investigate a number of methyl transfer enzymes. Quantum chemical methodology is today a very important tool in the elucidation of properties and reaction mechanisms of enzyme active sites. READ MORE