Search for dissertations about: "OSU6162"

Showing result 1 - 5 of 7 swedish dissertations containing the word OSU6162.

  2. 1. Dopaminergic stabilizers for the treatment of schizophrenia. Rat studies focusing on negative symptoms and mechanisms of action

    Author : Johan P. Rung; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ACR16; dopaminergic stabilizers; -MK-801; motor activity; negative symptoms; - -OSU6162; prolactin; rat; schizophrenia; social withdrawal;

    Abstract : Schizophrenia is a severe mental disorder manifested by positive, negative and cognitive symptoms. Current antipsychotic drugs have poor effects on negative and cognitive symptoms, thus necessitating the development of new antipsychotic treatments. Dopaminergic stabilizers constitute a novel concept for the treatment of schizophrenia. READ MORE

  4. 2. Fatigue after traumatic brain injury : exploring novel methods for diagnosis and treatment

    Author : Nils Berginström; Anna Nordström; Peter Nordström; Lars Nyberg; Jan Lexell; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic brain injury; fatigue; OSU6162; randomized clinical trials; functional magnetic resonance imaging; neuropsychology; structural magnetic resonance imaging; white matter hyperintensities; rehabiliteringsmedicin; Rehabilitation Medicine;

    Abstract : Background: Traumatic brain injury (TBI) is one of the most common causes of disability and mortality. While some patients recover quickly, especially at the mild side of the injury severity continuum, many will experience symptoms for years to come. READ MORE

  5. 3. Functional consequences of dopaminergic degeneration : Clinical and experimental studies using a novel stabilizer of dopaminergic systems

    Author : Anna Ekesbo; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; positron emission tomography; 6-OHDA; MPTP; dyskinesia; dopaminergic degeneration; - -OSU6162; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Abstract : Since the introduction of levodopa for the treatment of Parkinson's disease (PD) 30 yearsago, the emergence of motor complications, such as levodopa-induced dyskinesias (LID), hasbeen a major clinical problem in advanced stages of the disease. Clinical and preclinical studieshave revealed a number of functional changes in the dopaminergic system that may be ofimportance for the emergence of LIDs. READ MORE

  6. 4. The monoamine stabilizer (-)-OSU6162 : a potential novel treatment for alcohol use disorders

    Author : Ida Fredriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alcohol use disorder (AUD) represent a major health problem worldwide. Despite the severe consequences of AUD, only four medications are approved in Sweden for this disease. In addition, the prescription rates are low, partly due to varying clinical efficacy of these medications. Consequently, new, more effective pharmacotherapies are needed. READ MORE

  7. 5. The role of the dopamine system in the ability of (-)-OSU6162 to reduce voluntary alcohol drinking and binge-eating in the rat

    Author : Kristin Feltmann; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : BACKGROUND AND AIMS: The dopamine system is involved in the reinforcing effects of both food and alcohol and is thus a potential treatment target for alcohol use disorder (AUD) and binge-eating disorder (BED). Alcohol use disorder is characterized by difficulties to control alcohol drinking and by drinking despite adverse consequences. READ MORE