Search for dissertations about: "OX40"

Found 4 swedish dissertations containing the word OX40.

  2. 1. Role of the OX40 ligand/receptor pair in coronary artery disease

    Author : Massimiliano Ria; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Atherosclerosis is the pathological basis for coronary artery disease (CAD), the leading cause of morbidity and mortality in developed countries. CAD and atherosclerosis have long been known to have a familial component and result from the interaction of several genes with a wide range of environmental and lifestyle factors. READ MORE

  4. 2. Tumor necrosis factor superfamily members CD137 and OX40 ligand in vascular inflammation

    Author : Leif Söderström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Atherosclerosis, an inflammatory disease, is the major cause of cardiovascular disease - the main cause of death worldwide. T cells are central orchestrators of inflammation in atherosclerosis and critically depend on costimulation for adequate function. READ MORE

  5. 3. Genetic and immunological control of human myasthenia gravis

    Author : Xiaoyan Zhao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Myasthenia Gravis MG ; beta2-adrenergic receptor beta2-AR ; CCR2; CCR5; cytolytic T lymphocyte-associated antigen-4 CTLA-4 ; OX40;

    Abstract : Myasthenia gravis (MG) is a classical autoimmune disease characterized by muscle weakness due to an immune attack against the nicotinic acetylcholine receptor (AChR) on the post-synaptic membrane of the neuromuscular junction. Because of the involvement of multiple factors in the disease, the overall aims of this thesis were to uncover the regulation of candidate genes and the possible cellular mechanisms involved in the immuno-regulation of human MG. READ MORE

  6. 4. Immunomodulation of collagen-induced arthritis

    Author : Lars Mattsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : autoimmunity; arthritis; collagen type II; immunomodulation; vitamin D; parasite;

    Abstract : Collagen-induced arthritis (CIA) is an experimental autoimmune disease sharing many features with human rheumatoid arthritis (RA). CIA development is dependent on T-cells but anti-collagen type II (anti-CII) antibody production by B-cells is also important. READ MORE