Search for dissertations about: "Obesity and Type 2 diabetes"

Showing result 21 - 25 of 282 swedish dissertations containing the words Obesity and Type 2 diabetes.

2. 21. Bariatric surgery as treatment of type 2 diabetes – clinical and mechanistic aspects

   Author : Petros Katsogiannos; Jan Eriksson; Magnus Sundbom; Per-Ola Carlsson; Daniel Andersson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Roux-en-y gastric bypass; Type 2 diabetes; incretins; cytokines; adipokines; adipose tissue; heart rate variability; quality of life.; Medicinsk vetenskap; Medical Science;

   Abstract : Bariatric surgery can rapidly improve glycemic control and cardiovascular risk factors in patients with T2D and obesity. These improvements appear to be partly independent of weight loss, however, the underlying mechanisms remain incompletely understood. READ MORE

4. 22. Genetics of Diabetes Subtypes. Characterization of novel cluster-based diabetes subtypes

   Author : Dina Mansour Aly; diabetes och endokrinologi Genomik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Precision medicine; Diabetes Subclassification; genome-wide association studies; GWAS; genetic risk scores; GRS; chronic kidney disease; CKD; diabetic kidney disease; DKD; Estimated glomerular filtration rate; eGFR; ANDIS; diabetes; diabetics;

   Abstract : BACKGROUND: Type 2 diabetes (T2D) has been reproducibly clustered into five subtypes based on six-clinical variables; age at diabetes onset, body mass index (BMI), Glutamic acid decarboxylase autoantibodies (GADA), glycated hemoglobin (HbA1c) and insulin secretion and resistance estimated as HOMA2B and HOMA2IR derived from fasting glucose and Cpeptide. These subtypes have different disease progression and risk of complications. READ MORE

5. 23. Exploring the Grey Zone between Type 1 and Type 2 Diabetes

   Author : Ekaterine Bakhtadze; diabetes och endokrinologi Genomik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : T1D is most common in children and young adults and is characterized by autoimmune destruction of insulin producing pancreatic beta cells, presence of certain risk genotypes such as HLA-DQB1, INS VNTR, PTPN22 and need of insulin for survival. In adults the same situation is often referred to as Latent Autoimmune Diabetes in Adults (LADA), with age at onset after 35 years and non-insulin requiring at least for 6 month after diagnosis. READ MORE

6. 24. Effects of gastric bypass surgery in patients with obesity and type 2 diabetes

   Author : Vasileios Liakopoulos; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gastric bypass; bariatric surgery; obesity; type 2 diabetes mellitus; cardiovascular disease; mortality; risk factors; renal disease; adverse events;

   Abstract : Background: The effects of Roux-en-Y gastric bypass (GBP) have not been adequately explored in patients with concurrent obesity and type 2 diabetes mellitus (T2DM) to the same extent as has occurred for individuals with obesity alone. The overall aim of this thesis is to thoroughly examine the effects of GBP surgery in patients with obesity and T2DM in terms of cardiovascular disease and mortality, changes in various comorbidities, risk factors, and renal function as well as reporting adverse events. READ MORE

7. 25. Pathogenesis of type 2 diabetes -role of defects in insulin secretion and insulin sensitivity

   Author : Devjit Tripathy; Malmö Institutionen för kliniska vetenskaper; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; sekretion; diabetologi; Endocrinology; secreting systems; Calpain 10 gene; genetics of type 2 diabetes; MODY; Endogenous glucose production; Disposition index; Botnia clamp; IGT; IFG; HOMA; insulin sensitivity; insulin secretion;

   Abstract : Type 2 diabetes is characterised by defects in insulin sensitivity, insulin secretion and increased endogenous glucose production. The relative contribution of each of these defects remains controversial. READ MORE