Search for dissertations about: "Ocb"

Found 4 swedish dissertations containing the word Ocb.

  2. 1. Conquering complexity : successful strategies for finding disease genes in multiple sclerosis

    Author : Kerstin Imrell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple sclerosis (MS) is a complex disease; at an intra-individual level several contributory factors cause the disease; at an inter-individual level different factors contribute to the disease. The aim of the thesis project was to reduce this complexity by focusing of subsets of patients that were likely to share to a higher extent contributory causes and to identify in these subsets genes conferring susceptibility. READ MORE

  4. 2. Markers of inflammation and neurodegeneration in muliple sclerosis

    Author : Virginija Danylaitė Karrenbauer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The main line of my thesis projects is searching for biomarkers and evidence of optimal correlation with clinical and para-clinical outcome measurements in multiple sclerosis (MS): investigating the biochemical biomarker in blood/plasma (cerebrosterol) and in cerebrospinal fluid (CSF) (oligoclonal bands (OCB)) and the correlation with MRI lesion load (paper 1 and paper IV); investigating the genetic biomarker (CYP46A1) for susceptibility and disability progression in MS (Paper III); comparison of the well-known positron emission tomography (PET) ligand and peripheral benzodiazepine receptor (PBR) antagonist, [11C]PK11195, and a new PET ligand [11C]vinpocetine (tissue receptor biomarker). Both ligands denote areas of active ongoing inflammation in MS (paper II). READ MORE

  5. 3. Anti-drug antibodies in patients with multiple sclerosis

    Author : Malin Ryner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple sclerosis (MS) is an inflammatory disease affecting the brain and spinal cord and it is the main cause of neurological disability among young adults. Recombinant interferon beta (IFNβ) and natalizumab are commonly used disease-modifying drugs that reduce disease severity. READ MORE

  6. 4. Investigation of immunological preconditions in MS patients "MS immunopathic trait"

    Author : Sara Haghighi; Göteborgs universitet; []
    Keywords : multiple sclerosis; siblings; CSF; oligoclonal; cytokine; sulfatide; genetics; trait;

    Abstract : We examined 47 MS patients, 47 healthy siblings and 50 healthy unrelated individuals with blood and CSF analysis and found that 19 % (9/47) of healthy siblings of clinically definite multiple sclerosis patients had an intrathecal immunological reaction to ¡Ý 2 CSF-enriched OCB, in contrast to 4% (2/50) of the unrelated healthy controls. We termed this condition ¡°MS immunopathic trait¡±. READ MORE