Search for dissertations about: "Oligopeptides pharmacology"

Found 2 swedish dissertations containing the words Oligopeptides pharmacology.

  2. 1. Preclinical Development of New Alkylating Oligopeptides for Cancer Therapy

    Author : Joachim Gullbo; Rolf Larsson; Peter Nygren; Staffan Eriksson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; pharmacology; oncology; chemistry; Melphalan derivatives; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Abstract : Oligopeptides can be used to carry cytotoxic agents in cancer chemotherapy, using tumour-associated proteins as the molecular target for selectivity. During the seventies and eighties Peptichemio, a cocktail of six alkylating oligopeptides carrying m-L-sarcolysin, was investigated in a wide variety of human malignancies. READ MORE

  4. 2. Development and application of new methods for anticancer drug discovery and early evaluation

    Author : Sumeer Dhar; Uppsala universitet; []
    Keywords : Medical sciences; Drug development; tumor cell lines; cytotoxic drugs; neural network; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Abstract : A non-clonogenic assay using the redox dye Alamar Blue and primary human tumor cells (PHTC) from patients and human tumor cell lines (HTCL) was established for rapid screening and evaluation of anticancer drugs. PHTC cultures from chronic lymphocytic leukemia (CLL) and ovarian carcinoma (Ovca) were compared with renal carcinoma (ACHN) and lymphocytic (CCRF-CEM) HTLCs in response to 63 toxic or non-toxic compounds. READ MORE