Search for dissertations about: "Oligopeptides"
Showing result 1 - 5 of 9 swedish dissertations containing the word Oligopeptides.
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1. Preclinical Development of New Alkylating Oligopeptides for Cancer Therapy
Abstract : Oligopeptides can be used to carry cytotoxic agents in cancer chemotherapy, using tumour-associated proteins as the molecular target for selectivity. During the seventies and eighties Peptichemio, a cocktail of six alkylating oligopeptides carrying m-L-sarcolysin, was investigated in a wide variety of human malignancies. READ MORE
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2. Computational Prediction Models for Proteolytic Cleavage and Epitope Identification
Abstract : The biological functions of proteins depend on their physical interactions with other molecules, such as proteins and peptides. Therefore, modeling the protein-ligand interactions is important for understanding protein functions in different biological processes. READ MORE
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3. Synthesis of degradable aliphatic polyesters: strategies to tailor the polymer microstructure
Abstract : Key factors for successful tissue engineering are the synthesis and design of the scaffold materials. Aliphatic polyesters have been studied and often used as scaffold materials for tissue engineering. However, their lack of biological cues and degradation under high-temperature processing (e.g. READ MORE
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4. Activation and inhibition of diiron and iron-manganese ribonucleotide reductases
Abstract : Ribonucleotide reductase (RNR) catalyses the reduction of ribonucleotides to deoxyribonucleotides. In conventional class I RNRs the active site is located in the R1 subunit, and the R2 subunit contains a diiron cofactor and a stable tyrosyl radical essential for activity. READ MORE
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5. Light-Triggered Conformational Switches for Modulation of Molecular Recognition : Applications for Peptidomimetics and Supramolecular Systems
Abstract : The main focus of this thesis is on photochemical modulation of molecular recognition in various host-guest systems. This involves the design, synthesis and integration of light-triggered conformational switches into peptidomimetic guests and molecular tweezer hosts. READ MORE