Search for dissertations about: "Oliver Kappe"

Found 1 swedish dissertation containing the words Oliver Kappe.

2. 1. Synthesis and functionalization of ring-fused 2-pyridones : Targeting pili formation in E. coli

   Author : Nils Pemberton; Fredrik Almqvist; Oliver Kappe; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; 2-pyridone; acylketene; antibacterial; biofilm inhibitor; Mannich; Micro-wave-assisted chemistry; peptidomimetic; virulence.; Organic synthesis; Organisk syntes;

   Abstract : Bicyclic dihydrothiazolo fused 2-pyridones have been studied as a new class of antibacterial agents, termed pilicides, that target the formation of adhesive bacterial surface organelles (pili) in pathogenic bacteria. Synthetic methods to further functionalize the bicyclic 2-pyridone scaffold have been developed in order to increase water-solubility and thereby facilitate biological evalua-tions. READ MORE