Search for dissertations about: "Omics analysis"

Showing result 11 - 15 of 80 swedish dissertations containing the words Omics analysis.

  2. 11. Improved statistical methodology for high-throughput omics data analysis

    Author : Wenjiang Deng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Over the last two decades, the advent of high-throughput omics technology has substantially revolutionized biological and biomedical research. A large volume of omics data has been produced with the rapid development of sequencing techniques. READ MORE

  4. 12. The Dark side of Obesity: Multi-omics analysis of the dysmetabolic morbidities spectrum

    Author : Dimitra Lappa; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; systems biology; Obesity; multi-omics integration; biomarkers; gallstones; non-alcoholic fatty liver disease; GPCR receptors; metabotyping; bariatric surgery; self-organizing maps;

    Abstract : Obesity is one of the most prevalent clinical conditions worldwide and is associated with a wide spectrum of dysmetabolic comorbidities. Complex cardio-metabolic disease cohorts, such as obesity cohorts are characterised by population heterogeneity, multiple underlying diseases status and different comorbidities’ treatment regiments. READ MORE

  5. 13. Systems Biology of Protein Secretion in Human Cells: Multi-omics Analysis and Modeling of the Protein Secretion Process in Human Cells and its Application

    Author : Rasool Saghaleyni; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Erythropoietin; cancer protein secretory pathway; protein secretion modeling; HEK293; protein secretion; Integrative omics analysis; genome-scale modeling;

    Abstract : Since the emergence of modern biotechnology, the production of recombinant pharmaceutical proteins has been an expanding field with high demand from industry. Pharmaceutical proteins have constituted the majority of top-selling drugs in the pharma industry during recent years. READ MORE

  6. 14. On metabolic networks and multi-omics integration

    Author : Rasmus Ågren; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; succinate; genome-scale metabolic model; metabolic engineering; systems biology; penicillin; NASH; flux balance analysis; metabolism; cancer; reconstruction;

    Abstract : Cellular metabolism is a highly complex chemical system, involving thousands of interacting metabolites and reactions. The traditional approach to understanding metabolism has been that of reductionism; by isolating and carefully measuring the involved components, the goal has been to understand the whole as the sum of its parts. READ MORE

  7. 15. Model-Based Hypothesis Testing in Biomedicine : How Systems Biology Can Drive the Growth of Scientific Knowledge

    Author : Rikard Johansson; Gunnar Cedersund; Tomas Strömberg; Peter Strålfors; Marija Cvijovic; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; systems biology; modeling; ODE; hypothesis testing; falsificationism; insulin signaling; yeast; population heterogeneity; cell-to-cell variation; facilitation; pyramidal; synaptic; bootstrapping; personalized medicine; omics;

    Abstract : The utilization of mathematical tools within biology and medicine has traditionally been less widespread compared to other hard sciences, such as physics and chemistry. However, an increased need for tools such as data processing, bioinformatics, statistics, and mathematical modeling, have emerged due to advancements during the last decades. READ MORE