Search for dissertations about: "Oncogene Proteins"

Showing result 11 - 15 of 62 swedish dissertations containing the words Oncogene Proteins.

  2. 11. Immunological aspects of papillary thyroid carcinoma

    Author : Steven D. Lucas; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Papillary thyroid carcinoma; immunology; tumor antigens; RET proto-oncogene; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : Papillary thyroid carcinoma (PTC) is a puzzling disease. Although approximately 70% of patients with PTC have regional lymph node metastases at initial surgery, the long term survival is over 95%. READ MORE

  4. 12. Stress and immune signaling in a Drosophila tumor model

    Author : Dilan Khalili; Ulrich Theopold; Mirka Uhlirova; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drosophila; cancer; innate immunity; fibrosis; antimicrobial peptides; chitinase-like proteins; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Cancer cells contain multiple biological alterations that allow them to escape from host surveillance mechanisms. One of the mechanisms that play an essential role in host protection against tumor growth is immunity. READ MORE

  5. 13. Structure and function in c-Myc and Grx4 : two key proteins involved in transcriptional activation and oxidative stress

    Author : Malin Fladvad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The proto-oncogene c-myc is critical for growth and development and deregulation of c-myc expression affects the initiation and expansion of a wide range of human cancers, many of them aggressive. cMyc is a multi-domain protein, where it's C-terminal basic helix-loop-helix leucine zipper (bHLH-Zip) domain heterodimerizes with Max to accomplish gene regulatory activity. READ MORE

  6. 14. Targeting of the Myc pathway as a novel approach for cancer therapy

    Author : Hao Mo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : oncogene; tumor suppressor gene; Myc; cellular screening; small molecules; MYRAs; NSC308848; camptothecin; paclitaxel; apoptosis; transcription; transformation.;

    Abstract : As transcription factors, Myc-family proteins function upstream of signaling pathways and regulate cell proliferation, differentiation, angiogenesis, apoptosis and transformation. Precisely regulated Myc expression is critical for cellular physiology, while perturbations of Myc expression have detrimental consequences to the organism. READ MORE

  7. 15. Molecular mechanisms involved in the growth of human uterine leiomyomas

    Author : Xuxia Wu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Human uterine leiomyomas; myometrium; the menstrual cycle; estrogen; progesterone; cellular proliferation; apoptosis; oncogene; growth factor; growth factor receptor.;

    Abstract : Human uterine leiomyomas (fibroids) are benign neoplasms arising from uterine smooth muscle cells, and are suggested to be sex steroid dependent. The aim of this study was to investigate the molecular mechanisms by which sex steroids, mainly estrogen and progesterone, influence the growth of Ieiomyomas. READ MORE