Search for dissertations about: "Oncogene Proteins"

Showing result 16 - 20 of 62 swedish dissertations containing the words Oncogene Proteins.

  2. 16. Glial cell line-derived neurotrophic factor : expression patterns, neuronal transport, regulation, effects, and receptor dependence

    Author : Andreas C Tomac; Karolinska Institutet; Karolinska Institutet; []
    Keywords : glial cell line-derived neurotrophic factor GDNF ; neurturin NTN ; persephin PSP ; c Ret proto oncogene Ret ; GPI-linked receptors for the GDNF ligand family GFRas ; transforming growth factor-B TGFB ; Parkinson s disease PD ; dopaminergic DA neurons;

    Abstract : Background: The mammalian nervous system depends upon trophic proteins for survival, growth and adult maintenance. These trophic factors have also been considered as potential therapeutic agents for treating human neurodegenerative disorders. READ MORE

  4. 17. Chromatin remodelling in Pol I and III transcription

    Author : Erica Cavellán; Ann-Kristin Östlund Farrants; Gernot Längst; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell biology; Cellbiologi;

    Abstract : Compaction of chromosomes in the eukaryotic cell is due to interactions between DNA and proteins and interactions between proteins. These two types of interaction form a dynamic structure, known as "chromatin". The condensation of chromatin must be carefully regulated, since the structure is an obstacle for factors that need access to the DNA. READ MORE

  5. 18. Functional adaptation of c-Myc and its role in lymphoma-associated gene regulation

    Author : Amir Nematollahi Mahani; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The Myc proto-oncogene, is a highly disordered (lack of structure formation) transcription factor (TF), which can bind to its partner proteins and regulate different biological functions of the cells including proliferation, cell cycle, differentiation and apoptosis. In general, Myc deregulation is a major prime force in human tumors, which contributes to their uncontrolled cell proliferation, metastasis and tumor cell immortalizations. READ MORE

  6. 19. Aspects of MEN1 Tumorigenesis in Endocrine Pancreas and Adrenal Glands

    Author : Xia Chu; Kjell Öberg; Barbro Eriksson; Magnus Kjellman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEN1; tumorigenesis; PNET; angiogenesis; adrenal glands; proteomic analysis; miRNA expression; Oncology; Onkologi;

    Abstract : Multiple endocrine neoplasia syndrome type 1 (MEN1) is an autosomal dominantly inherited disease, which is described as an association of tumors mainly in endocrine organs, including pancreas and adrenal glands. Pancreatic neuroendocrine tumors (PNETs) are the most common cause of death in MEN1 patients. READ MORE

  7. 20. Molecular genetics of cutaneous malignant melanoma

    Author : Malihe Eskandarpour; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cutaneous malignant melanoma is an aggressive tumor of melanocytes in the skin with rapidly increasing incidence. Patients with advanced disease have a poor prognosis since the tumor is usually resistant to current therapies. Therefore, the development of novel strategies for preventing and treating melanoma is important. READ MORE