Search for dissertations about: "Opioids"

Showing result 21 - 25 of 103 swedish dissertations containing the word Opioids.

2. 21. Differential effects of voluntary running on hippocampal plasticity in the adult rat brain

   Author : Andrew Stuart Naylor; Göteborgs universitet; []
   Keywords : exercise; hippocampus; stress; progenitor proliferation; neurogenesis; trophic factors; frontal cortex; spatial memory; rat; pCREB; endogenous opioids;

   Abstract : The continuation of neuronal birth from dividing neural stem cells in the dentate gyrus of the hippocampus throughout adulthood is known to play an important role in maintaining normal hippocampal function, such as memory and learning. Negative alterations in the levels of adult neurogenesis have also been linked to several neurodegenerative diseases, including Alzheimer s disease and mood disorders such as depression. READ MORE

4. 22. Long-term Effects of Opioids in the Treatment of Chronic Pain : Investigation of Problems and Hazards on Clinical, Biochemical, Cellular and Genetic Levels

   Author : Annica Rhodin; Torsten Gordh; Fred Nyberg; Mats Stridsberg; Mats Enlund; Harald Breivik; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; opioid; chonic pain; long-term opioid treatment; Anaesthetics; Anestesiologi; Anestesiologi; Anaesthesiology;

   Abstract : After two decades of liberal prescribing of opioids, there has been an increasing recognition of problems connected to the prolonged use of opioids for chronic pain. The aim of my thesis was to explore some consequences of long-term opioid treatment for chronic pain such as problematic opioid use, endocrine disorders, tolerance and genetic variations in pain and opioid response. READ MORE

5. 23. Opioids regulate proliferation of neural progenitors. A study on the effects of opioids on adult rat hippocampal progenitors in vitro and in vivo

   Author : Anders I. Persson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Opioid; brain; hippocampus; rat; neurogenesis; progenitor; stem cell; b-endorphin; calcium; MAPK;

   Abstract : The opioid receptors were among the first pharmacologically described brain receptors. These opioid receptors have thereafter been shown to mediate effects on proliferation and differentiation in both the embryonal and adult central nervous system. READ MORE

6. 24. Neuropeptide release in the rat dorsal horn in models of persistent pain : effects of opioids

   Author : Abdullahi Warsame Afrah; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Axotomy; Inflammation; Long term potentiation; Capsaicin; Opioids; Cholecystokinin; Substance P; Glutamate; NMDA; Spinal cord; Microdialysis; Radioimmunoassay.;

   Abstract : Nerve injury and tissue inflammation may lead to exaggerated responses to both noxious stimuli (hyperalgesia) and innocuous stimuli (allodynia). Altered release pattems of neurotransmitters in the dorsal hom of the spinal cord have been suggested to contribute to hyperalgesia and allodynia. READ MORE

7. 25. Genetic factors and the role of the NMDA receptor in pain modulation and the effect of opioids

   Author : Aida Plesan; Karolinska Institutet; Karolinska Institutet; []
   Keywords : pain; NMDA-receptor antagonists; genetic difference; rat strain; opioids; methadone; morphine tolerance; neuropathic pain;

   Abstract : Pain perception and the response to opioid analgesics are determined by a number of factors, among which genetic variability and the activation of the NMDA-receptor for glutamate play an important role. The effects of two clinically available NMDA-receptor antagonists, ketamine (KET) and dextromethorphan (DEX), were evaluated on an animal model of acute nociception, the hot plate test, and on human experimental acute ischemic pain. READ MORE