Search for dissertations about: "Optimal experimental design"

Showing result 1 - 5 of 119 swedish dissertations containing the words Optimal experimental design.

  1. 1. Experimental Designs at the Crossroads of Drug Discovery

    University dissertation from Umeå : Kemi

    Author : Ing-Marie Olsson; Svante Wold; Johan Gottfries; Michael Sjöström; Bo Nordén; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; Design of experiments; Experimental design; Multivariate data-analysis; D-optimal design; 96-well technology; Drug discovery; Assay optimisation; QSAR; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Abstract : New techniques and approaches for organic synthesis, purification and biological testing are enabling pharmaceutical industries to produce and test increasing numbers of compounds every year. Surprisingly, this has not led to more new drugs reaching the market, prompting two questions – why is there not a better correlation between their efforts and output, and can it be improved? One possible way to make the drug discovery process more efficient is to ensure, at an early stage, that the tested compounds are diverse, representative and of high quality. READ MORE

  2. 2. Practical Optimal Experimental Design in Drug Development and Drug Treatment using Nonlinear Mixed Effects Models

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Joakim Nyberg; Andrew C. Hooker; Mats O. Karlsson; Sergei Leonov; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; robust design; optimizing drug development; population models; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : The cost of releasing a new drug on the market has increased rapidly in the last decade. The reasons for this increase vary with the drug, but the need to make correct decisions earlier in the drug development process and to maximize the information gained throughout the process is evident. READ MORE

  3. 3. Achievement tests and optimal design for pretesting of questions

    University dissertation from Department of Statistics, Stockholm University

    Author : Mahmood Ul Hassan; Frank Miller; Steven Gilmour; [2019]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Achievement test; Equivalence theorem; Exchange algorithm; Item calibration; Item response theory model; Optimal experimental design; statistik; Statistics;

    Abstract : Achievement tests are used to measure the students' proficiency in a particular knowledge. Computerized achievement tests (e.g. GRE and SAT) are usually based on questions available in an item bank to measure the proficiency of students. READ MORE

  4. 4. Benefits of Non-Linear Mixed Effect Modeling and Optimal Design Pre-Clinical and Clinical Study Applications

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Charles Ernest II; Andrew Hooker; Mats Karlsson; Bart Ploeger; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; population models; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Despite the growing promise of pharmaceutical research, inferior experimentation or interpretation of data can inhibit breakthrough molecules from finding their way out of research institutions and reaching patients. This thesis provides evidence that better characterization of pre-clinical and clinical data can be accomplished using non-linear mixed effect modeling (NLMEM) and more effective experiments can be conducted using optimal design (OD). READ MORE

  5. 5. Diffractive Optics Design

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Jörgen Bengtsson; [1997]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; computer-generated waveguide hologram; diffractive optics; fan-out; millimeter wave radiation; proximity effect; optimal-rotation-angle method; kinoform; integrated optics; beam shaping; outcoupling grating; scalar optics;

    Abstract : Diffractive optical elements (kinoforms) change the way light propagates, and can perform very complex tasks. They can split an incident beam into any number of outgoing, and possibly focused, beams (fan-out). READ MORE