Search for dissertations about: "Optimal experimental design"

Showing result 11 - 15 of 164 swedish dissertations containing the words Optimal experimental design.

  2. 11. Towards optimized instrument panels

    Author : Carl Jörgen Normark; Luleå tekniska universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Industrial Design; Industriell design;

    Abstract : Today, automobiles are becoming more and more technologically complex, with more and more built-in driver information systems. This increases the amount and range of information the driver needs to be aware of while driving. READ MORE

  4. 12. Design, Optimization and Evaluation of a Transonic Aeroelastic Rig

    Author : Simeng Tian; Andrew R. Martin; Mauricio Gutierrez Salas; Dieter Peitsch; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Transonic compressor; Aeroelastic rig; Design; CFD; Unsteady flow; Energiteknik; Energy Technology;

    Abstract : The compressor is one of the most essential components of a modern turbomachinery engine. This component is exposed to vibrations that without proper design can damage structural integrity and lead to failure. READ MORE

  5. 13. Multi-objective CFD-based design method for axial compressors

    Author : Lars R Ellbrant; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Q3D; Turbomachinery; Design; Meta-modeling; Optimization; CFD; Validation; Compressor; Transonic;

    Abstract : Economic aspects such as reducing specific fuel consumption and ever growing environmental requirements on emissions and perceived noise levels are the major incentives in the pursuit to improve aircraft engines. The overall efficiency of the engine is a combination of propulsive efficiency and thermal efficiency. READ MORE

  6. 14. Mixed Effects Modelling and Optimal Design of TNFα Response in LPS Challenge Studies - Methods and Applications in Drug Discovery

    Author : Julia Larsson; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; pharmacodynamics; pharmacokinetics; non-linear mixed effects modelling; lipopolysaccharides; tumour necrosis factor alpha; optimal design;

    Abstract : ''Endotoxin and mycoplasma are Nature’s darkest secrets. If they are ever solved, Hell itself will open.'' - Lewis Thomas* Endotoxin, or lipopolysaccharides (LPS), are heterogeneous components from the cell wall of Gram-Negative bacteria and a common challenger in the field of drug discovery. READ MORE

  7. 15. Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation

    Author : Erik Sjögren; Hans Lennernäs; Scott Obach; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatic disposition; pharmacokinetics; mechanistic modelling; drug-drug interactions; enzyme kinetics; Vmax; Km; CLint; carrier-mediated transport; active transport; modelling; in vitro-in vivo extrapolation; physiologically based pharmacokinetic model; optimal experimental design; experimental optimization; data analysis optimization; PHARMACY; FARMACI; Biopharmacy; Biofarmaci; Biopharmaceutics; Biofarmaci;

    Abstract : The elimination of drugs from the body is in many cases performed by the liver. Much could be gained if an accurate prediction of this process could be made early in the development of new drugs. However, for the elimination to occur, the drug molecule needs first to get inside the liver cell. READ MORE