Search for dissertations about: "Oral formulation"

Showing result 1 - 5 of 23 swedish dissertations containing the words Oral formulation.

  1. 1. Ceramic Materials for Administration of Potent Drugs

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Bing Cai; Uppsala universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Tamper-resistance; Oral formulation; Transdermal formulation; Biomaterials; Microneedles;

    Abstract : This thesis aimed to investigate and document the potential of applying ceramics in two specific drug delivery applications: tamper-resistant opioid formulations and transdermal enhancement protrusions.Geopolymers were developed into the matrix for a tamper-resistant formulation, aiming to protect drug substances from non-medical abuse. READ MORE

  2. 2. Improved Molecular Understanding of Lipid-Based Formulations for Enabling Oral Delivery of Poorly Water-Soluble Drugs

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Linda C. Alskär; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipid-based formulation; poorly water-soluble drug; solubility prediction; molecular properties; lipid digestion; precipitation; solid state; intestinal solubilization; in vitro in vivo correlation IVIVC ; coadministration; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The majority of emerging drug candidates are not suited for conventional oral dosage forms, as they do not dissolve in the aqueous environment of the gastrointestinal (GI) tract. Consequently, a large number of enabling formulation strategies have emerged. READ MORE

  3. 3. Development of a New Oral Vaccine against Diphtheria and the Study of its Immunogenicity in Mouse and Man

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Niclas Rydell; Uppsala universitet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; oral vaccination; mucosal vaccination; diphtheria; biodegradable; microparticles; starch; CRM197; adjuvant; vaccine; Galenisk farmaci; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci;

    Abstract : Most pathogens enter the body via mucosal surfaces. In contrast to parenterally administered vaccination, mucosal vaccination has the advantage of eliciting both a systemic and a local mucosal immune response. An oral biodegradable adjuvant with these features would have great potential. READ MORE

  4. 4. Geopolymer-based drug formulations for oral delivery of opioids

    University dissertation from Uppsala : Uppsala University, Department of Engineering Sciences

    Author : Bing Cai; Uppsala universitet.; [2014]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Abstract : Opioid therapy for chronic pain generally use controlled release formulations to deliver analgesic drugs around-the-clock. Controlled release dosage forms can enlarge the therapeutic effect by controlling the rate and site of release. However, with high drug content, opioid formulations are easily targeted for non-medical use. READ MORE

  5. 5. Studies on a Novel Powder Formulation for Nasal Drug Delivery

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Nelly Fransén; Uppsala universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nasal drug delivery; nasal powder spray; interactive mixture; mucoadhesion; sodium starch glycolate; superdisintegrant; bioavailability; clinical trial; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci;

    Abstract : Nasal administration has potential for the treatment of indications requiring a fast onset of effect or for drugs with low oral bioavailability. Liquid nasal sprays are relatively common, but can be associated with suboptimal absorption from the nasal cavity; this thesis shows that nasal absorption can be significantly enhanced with a dry powder formulation. READ MORE