Search for dissertations about: "Orbitrap"

Showing result 1 - 5 of 6 swedish dissertations containing the word Orbitrap.

2. 1. Toxicometabolomics and biotransformation product screening in single zebrafish embryos

   Author : Anton Ribbenstedt; Jonathan P. Benskin; Magnus Breitholtz; Elena Gorokhova; Emma Schymanski; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Non-target; REACH; Orbitrap; single embryo; zebrafish embryo; metabolism; high throughput; hydroxylation; glucuronidation; metabolite screening; phase I; phase II; pharmaceutical; structure elucidation; conjugation; propranolol; beta blocker; Non-targeted; toxicometabolomics; Orbitrap; single embryo; 3R; metabolomics; MoA; mode of action; zebrafish embryo; carbamazepine; biotransformation; Applied Environmental Science; tillämpad miljövetenskap;

   Abstract : Over the last decade environmental agencies worldwide have escalated their work to phase out animal testing for the purposes of chemical regulation. Meanwhile the number of commercially available chemicals and the requirements for hazard assessments have both increased, creating a large need for substitution of traditional in vivo assays with in vitro tests. READ MORE

4. 2. Characterization of dissolved organic matter : An analytical challenge

   Author : Claudia Patriarca; Jonas Bergquist; Lars Tranvik; Jeffrey A. Hawkes; Jonathan Martin; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Abstract : Dissolved organic matter (DOM) is the prevalent form of organic carbon in most aquatic environments. It is an ultra-complex mixture that plays a crucial role in global carbon cycling. Despite its importance it is still poorly understood due to its extreme heterogeneity and intricacy. READ MORE

5. 3. Novel methods of tandem mass spectrometry in life sciences

   Author : Mohammadhassan Gharibi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Mass spectrometry (MS) is a powerful analytical technique widely employed for isotopic analysis and species identification in numerous research fields. Isotopic analysis involves precisely measuring stable isotopes within a sample, offering valuable insights into its origin, environment, and biological processes. READ MORE

6. 4. Characterisation of natural dissolved organic matter with liquid chromatography and high resolution mass spectrometry

   Author : Claudia Patriarca; Jonas Bergquist; Lars Tranvik; Per J.R. Sjöberg; Jeffrey A. Hawkes; Norbert Hertkorn; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; aquatic carbon cycle; dissolved organic matter; DOM; high resolution mass spectrometry; online liquid chromatography; organic matter characterization; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Abstract : Dissolved organic matter (DOM) is one of the most heterogeneous and complex mixture on Earth. DOM plays a crucial role in biogeochemical processes on the global scale and it is essential to sustain and regulate the biological processes in aquatic ecosystems. READ MORE

7. 5. What contributes to human body burdens of phthalate esters? : An experimental approach

   Author : Georgios Giovanoulis; Cynthia A. de Wit; Jörgen Magnér; Brice Appenzeller; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Phthalates; Alternative plasticizers; DINCH; In vivo screening; Urine; Nails; Air; Dust; Hand wipes; Duplicate diet; Predictors of exposure; Applied Environmental Science; tillämpad miljövetenskap;

   Abstract : Phthalate esters (PEs) and alternative plasticizers used as additives in numerous consumer products are continuously released into the environment leading to subsequent human exposure. The ubiquitous presence and potential adverse health effects (e.g. READ MORE