Search for dissertations about: "Organic cation transporter 1"

Found 2 swedish dissertations containing the words Organic cation transporter 1.

  1. 1. In vitro and in silico prediction of drug-drug interactions with transport proteins

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Gustav Ahlin; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solute carrier; SLC transporter; OCT1; Organic cation transporter 1; SLC22A1; OATP1B1; SLCO1B1; Organic anion transporting peptide 1B1; Drug transport; Active transport; Genetic polymorphism; Cell lines; Gene expression; Multivariate data analysis; OPLS; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci; PHARMACY Biopharmacy; FARMACI Biofarmaci; galenisk farmaci; Pharmaceutics; Biopharmaceutics; biofarmaci;

    Abstract : Drug transport across cells and cell membranes in the human body is crucial for the pharmacological effect of drugs. Active transport governed by transport proteins plays an important role in this process. A vast number of transport proteins with a wide tissue distribution have been identified during the last 15 years. READ MORE

  2. 2. Monoamine transporters in female human reproduction

    University dissertation from Department of Obstetrics and Gynecology, Lund University

    Author : Barbara Bottalico; Lund University.; Lunds universitet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PMAT; VMAT2; OCT; NET; in-situ hybridization histochemistry; decidualization; human endometrium; placenta; Medicine human and vertebrates ; Monoamine transporters; preeclampsia; histamine; Medicin människa och djur ;

    Abstract : The present study explored the gene and protein expression of the monoamine transporters in human endometrium throughout the menstrual cycle, in early decidua and in placentas from normal as well as preeclamptic pregnancies using in-situ hybridization, real time-PCR, immunohistochemistry and primary tissue cultures. Four distinguishable patterns were observed in the endometrium over the menstrual cycle: (1) epithelial expression of norepinephrine transporter (NET) mRNA, (2) Stromal co- expression of vesicular monoamine transporter 2 (VMAT2) and plasma membrane monoamine transporter (PMAT) mRNAs with maximal intensity in the proliferative phase; (3) increasing epithelial expression of VMAT2 mRNA with a maximum in the late secretory phase; (4) stromal expression of extra-neuronal monoamine transporter (EMT) mRNA with a peak in the early secretory phase. READ MORE