Search for dissertations about: "Organic synthesis"

Showing result 1 - 5 of 653 swedish dissertations containing the words Organic synthesis.

  1. 1. Stereoselective Synthesis of Amino Alcohols : Applications to Natural Product Synthesis

    Author : Staffan Torssell; Peter Somfai; Pher G Andersson; KTH; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Amino alcohol; asymmetric 1.3-dipolar cycloaddition; azomethine ylide; carbenoid; carbonyl ylide; cross-metathesis; omuralide; oxazolidine; rhodium; sphingosine; stemoamide; stereoselective synthesis; total synthesis.; Organic chemistry; Organisk kemi;

    Abstract : This thesis is divided into four separate parts with amino alcohols as the common feature. The first part of the thesis describes the development of an efficient three-component approach to the synthesis of α-hydroxy-β-amino esters. READ MORE

  2. 2. Pheromone Synthesis : Conjugated Diene Systems and Oxygenated Carene Derivatives

    Author : Rikard Unelius; Torbjörn Norin; Lars Skatteböl; KTH Organic Chemistry; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; pheromone diene carene derivative; Organic Chemistry; Organisk kemi;

    Abstract : .... READ MORE

  3. 3. Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library

    Author : Fredrik Thorstensson; Ingemar Kvarnström; Charles Hedgecock; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; combinatorial synthesis; metathesis; olefin metathesis; thrombin; HCV; NS3; protease; proline isosteres; inhibitor; Organic synthesis; Organisk syntes;

    Abstract : Structure-based drug design and combinatorial chemistry play important roles in the search for new drugs, and both these elements of medicinal chemistry were included in the present studies. This thesis outlines the synthesis of protease inhibitors against thrombin and the HCV NS3 protease, as well as the synthesis of a combinatorial library using solid phase chemistry. READ MORE

  4. 4. Design and Synthesis of Serine and Aspartic Protease Inhibitors

    Author : Fredrik Wångsell; Ingemar Kvarnström; Olle Karlsson; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; metathesis; HCV; NS3; protease; proline isosteres; inhibitor; aspartic protease inhibitors; hydroxyethylene; Organic synthesis; Organisk syntes;

    Abstract : This thesis describes the design and synthesis of compounds that areintended to inhibit serine and aspartic proteases. The first part of the text deals with preparation of inhibitors of the hepatitis C virus (HCV) NS3 serine protease. Hepatitis C is predominantly a chronic disease that afflicts about 170 million people worldwide. READ MORE

  5. 5. Exploring the structure of oligo- and polysaccharides : Synthesis and NMR spectroscopy studies

    Author : Hanna Jonsson; Göran Widmalm; Antonio Molinaro; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; NMR spectroscopy; synthesis; lipopolysaccharides; conformational studies; Organic chemistry; Organisk kemi; Organic Chemistry; organisk kemi;

    Abstract : A deeper understanding of the diversity of carbohydrates and the many applications of oligo- and polysaccharides found in nature are of high interest. Many of the processes involving carbohydrates affect our everyday life. This thesis is based on six papers all contributing to an extended perspective of carbohydrate property and functionality. READ MORE