Search for dissertations about: "Organotypic cultures"

Showing result 1 - 5 of 23 swedish dissertations containing the words Organotypic cultures.

  1. 1. Auditory organotypic cultures and progenitor cell implantation

    Author : Andreas Kaiser; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : According to the WHO, about 5 % of the world’s population suffers from disabling hearing loss. In people above the age of 65 the number is more than 30 %. Common effects of this condition are poor speech discrimination and impaired communication abilities. Patient surveys show that hearing loss often leads to a diminished quality of life. READ MORE

  2. 2. Endoplasmic Reticulum Dynamic Structural Changes in Neurons: The Fission-Fusion Phenomena

    Author : Krzysztof Kucharz; Sektion IV; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fragmentation; fission; endoplasmic reticulum; neurons; FRAP; primary cultures; organotypic slice cultures; in vivo; in situ; calcium; fusion; NMDA receptor; 2-photon microscopy; confocal microscopy;

    Abstract : The endoplasmic reticulum (ER) is crucial for protein synthesis and protein maturation, is involved in cell stress and serves in neurons as the major intracellular Ca2+ store. Neuronal ER forms a continuous network of cisterns and tubules extending from soma to a subset of dendritic spines. READ MORE

  3. 3. Mechanisms of Ischemic Brain Injury- studies in murine hippocampal slice cultures

    Author : Anna Rytter; Sektion IV; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neuropsychology; Neurology; adenosine; caspases; hypothermia; in vitro; hippocampus; ischemia; neurofysiologi;

    Abstract : Cerebral ischemia is a major cause of mortality and morbidity in the western world. Even though much effort has been put into research and development of effective drugs against ischemic damage there is to date no effective pharmacological brain protective treatment. READ MORE

  4. 4. Characterization of hippocampal slice cultures as model systems for neurodegenerative processes in Alzheimer´s disease

    Author : Sara Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Alzheimer's disease (AD) is the most common cause of dementia and a growing health care problem worldwide. The disease affects different brain regions, including hippocampus, enthorhinal cortex, amygdala, neocortex and certain basal forebrain nuclei. Macroscopically, shrinkage of gyri and widening of sulci characterize the AD brain. READ MORE

  5. 5. Modeling of multi-step oral carcinogenesis in vitro : Assessment of growth, differentiation and apoptosis markers

    Author : Annette Hansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Organotypic cultures; apoptosis; terminal squamous differentiation; buccal mucosa; cytokeratins; carcinogenesis; p53;

    Abstract : Human oral mucosa, especially the buccal epithelium, is worldwide a common site for cancer. Cancer development frequently results in inactivation of tumor suppressor p53, a central regulator of growth and programmed cell death, and deregulated expression of structural elements like cytokeratins. READ MORE