Search for dissertations about: "Otto Berg"

Found 5 swedish dissertations containing the words Otto Berg.

  2. 1. Causes of Substitution Frequency Variation in Pathogenic Bacteria

    Author : Wagied Davids; Siv Andersson; Otto Berg; Bengt Persson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Comparative genomics; Molecular evolution; Bioinformatics; Human pathogens; Rickettsia; Helicobacter pylori; Biologi; Biology; Biologi;

    Abstract : Estimating substitution frequencies at sites that influence (Ka) and do not influence (Ks) the amino acid sequence is important for understanding the dynamics of molecular sequence evolution and the selective pressures that have shaped genetic variation. The aim of this work was to gain a deeper understanding of the driving forces of substitution frequency variation in human pathogens. READ MORE

  4. 2. Statistical models of TF/DNA interaction

    Author : Aymeric Fouquier d'Herouel; Erik Aurell; Otto Berg; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; gene expression; regulation; transcription factor; binding motif; matrix representations; gibbs sampling; binding affinity; non-specific binding; Biological physics; Biologisk fysik;

    Abstract : Gene expression is regulated in response to metabolic necessities and environmental changes throughout the life of a cell. A major part of this regulation is governed at the level of transcription, deciding whether messengers to specific genes are produced or not. READ MORE

  5. 3. Exploring and predicting DNA template dependent variation in transcription

    Author : Harriet Mellenius; Måns Ehrenberg; Johan Elf; Dan Andersson; Otto Berg; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; transcription; accuracy; kinetic proofreading; selection; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : Reliable transmission of information from DNA to proteins is a pre-requisite for all life, where substitution errors in the polypeptide chain may arise from transcription, aminoacylation of tRNAs or translation. The fidelity control mechanisms in transcription have nevertheless received little attention, based on the assumption that the transcriptional error is masked by the translational error. READ MORE

  6. 4. Modeling Genome Evolution : Creation, Change and Destruction

    Author : Mats Pettersson; Otto Berg; Paul Sniegowski; Uppsala universitet; []
    Keywords : Molecular biology; Theotretical biology; Population genetics; Stochastic modeling; Genome evolution; Molekylärbiologi;

    Abstract : Historically, evolution has been studied either by looking at morphological traits in living organisms and the fossil record, or by using bioinformatics and comparative genomics. While highly useful for deducing evolutionary history, these approaches are not particularly well suited for studying the mechanisms of evolution. READ MORE

  7. 5. Surviving the ratchet : Modelling deleterious mutations in asexual populations

    Author : Jonas Söderberg; Otto Berg; Laurence Loewe; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Theoretical biology; Population genetics; Stochastic modelling; Genome evolution; Muller s Ratchet; Genetics; Genetik; Organism biology; Organismbiologi; Biology; Biologi; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Abstract : One of the most unforgiving processes in nature is that of Muller's ratchet, a seemingly irreversible accumulation of deleterious mutations that all organisms have to deal with or face extinction. The most obvious way to avoid fitness collapse is recombination, though asexual populations usually do not have the luxury of recombining freely. READ MORE