Search for dissertations about: "Outi Vaarala"

Showing result 1 - 5 of 8 swedish dissertations containing the words Outi Vaarala.

2. 1. Studies of Mucosal Immune Regulation in Celiac Disease and Type 1 Diabetes

   Author : Anne Lahdenperä; Johnny Ludvigsson; Outi Vaarala; Rosaura Casas; Eva Sverremark-Ekström; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : Background: Celiac disease (CD) and type 1 diabetes (T1D) are two chronic autoimmune diseases with increasing incidence worldwide. A combination of genetic, environmental and immunological factors is considered to be involved in development of the diseases, even though the exact disease mechanisms still are unknown. READ MORE

4. 2. Immune responses to lipopolysaccharide in relation to allergic disease : a TLR4 gene polymorphism and endotoxin exposure

   Author : Anna Lundberg; Malin Fagerås Böttcher; Outi Vaarala; Marita Troye-Blomberg; Linköpings universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : Background: Allergic diseases have increased during the last decades, particularly in affluent countries, possibly due to a reduced and/or altered microbial exposure during infancy. Activation of the immune system by microbes early in life is probably required for accurate maturation of the immune system and tolerance development. READ MORE

5. 3. Genetic studies of diabetes in northern Sweden

   Author : Sofia Mayans; Dan Holmberg; Mats Eliasson; Outi Vaarala; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; families; genetic; association; SNP; linkage; TCF7L2; CTLA-4; Calpain-10; Medical genetics; Medicinsk genetik;

   Abstract : Diabetes mellitus represents a group of metabolic disorders caused by both environmental and genetic factors. The two most common forms of diabetes are type 2 diabetes (T2D) and type 1 diabetes (T1D). T2D is associated with obesity and the disease is caused by insulin resistance and pancreatic b-cell dysfunction. READ MORE

6. 4. Inflammatory Mediators and Enterovirus Infections in Human Islets of Langerhans

   Author : Annika Moëll; Gun Frisk; Olle Korsgren; Bo Nilsson; Outi Vaarala; Uppsala universitet; []
   Keywords : Immunology; diabetes; islets of Langerhans; enterovirus; inflammatory mediators; cytokines; nicotinamide; Immunologi;

   Abstract : Type 1 diabetes (T1D) is due to a selective loss of the insulin producing β-cells. However, the process responsible for this loss is still unknown. There is accumulating evidence that enteroviruses (EVs) are involved in T1D. In addition to direct virus-induced cytolysis, EVs could facilitate β-cell destruction by inducing inflammatory cytokines. READ MORE

7. 5. Early-life gut microbiota and breast milk oligosaccharides in relation to childhood immune maturation and allergy

   Author : Ylva Margareta Sjögren; Eva Sverremark-Ekström; Outi Vaarala; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; allergy; infant; gut microbiota; human milk oligosaccharides; Bifidobacterium; Lactobacillus; Bacteroides fragilis; Clostridium difficile; family size; secretory IgA; toll like receptor; Immunology; Immunologi; immunologi; Immunology;

   Abstract : Atopic allergy is the most common chronic disease among children in the developed world. This high prevalence could be associated with low microbial exposure. The early gut microbiota appears to be important for immune maturation. READ MORE