Search for dissertations about: "Oxycodone"

Showing result 1 - 5 of 6 swedish dissertations containing the word Oxycodone.

  1. 1. Pharmacokinetics and Pharmacodynamics of Oxycodone and Morphine with Emphasis on Blood-Brain Barrier Transport

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Emma Boström; Uppsala universitet.; [2007]
    Keywords : Pharmacokinetics Pharmacotherapy; pharmacokinetics; pharamcodynamics; blood-brain barrier; oxycodone; microdialysis; NONMEM; brain distribution; transport; Farmakokinetik Farmakoterapi;

    Abstract : The pharmacokinetics and pharmacodynamics of oxycodone and morphine was investigated and related to the transport across the blood-brain barrier (BBB) in rats. The influence of a P-glycoprotein (P-gp) inhibitor on the plasma pharmacokinetics and pharmacodynamics of oxycodone was evaluated. READ MORE

  2. 2. The effects of growth hormone on opioid-induced toxicity in vitro

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Erik Nylander; Uppsala universitet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; opioids; methadone; morphine; ketobemidone; fentanyl; oxycodone; hydromorphone; insulin-like growth factor; cell viability; NG108-15; SH-SY5Y; hippocampus; cortex; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : There is an ongoing opioid crisis in the United States that is portrayed by a large number of opioid-related deaths. Many of these cases involve commonly used prescription opioids, such as morphine, oxycodone, fentanyl, and methadone. This is concerning and highlights the problems associated with long-term opioid treatment. READ MORE

  3. 3. Pain relief following cesarean section : short and long term perspectives

    University dissertation from Stockholm : Karolinska Institutet

    Author : Boel Niklasson; Sophiahemmet Högskola.; Karolinska Institutet.; Karolinska Institutet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pain management; Local anesthesia; Cesarean section; Morphine consumption; Postoperative pain; Persistent pain; Risk factors; Quality of daily life; Multimodal treatment; Oxycodone; Codeine; Newborn; Safety; pain management;

    Abstract : BackgroundPostoperative pain treatment in women undergoing cesarean section (CS) needs to be effective to enable fast and smooth recovery without adverse outcomes and to improve breastfeeding and bonding between mother and child. It is also important that pain treatment should have minimal impact on the newborn. READ MORE

  4. 4. In Vivo Active Drug Uptake and Efflux at the Blood-Brain Barrier With Focus on Drug Transport Interactions

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Muhammad Waqas Sadiq; Uppsala universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Active uptake transport; Microdialysis; P-glycoprotein; Drug interactions; Species differences; Pharmacokinetics; Pharmacodynamics; NONMEM; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : The blood-brain barrier (BBB) controls the movement of substances into and out of the brain. The tight junctions between endothelial cells and energy dependent transporters in the BBB influence rate and extent of drug distribution to the brain. READ MORE

  5. 5. The monoamine stabilizer (-)-OSU6162 : a potential novel treatment for alcohol use disorders

    University dissertation from Stockholm : Karolinska Institutet, Dept of Clinical Neuroscience

    Author : Ida Fredriksson; Karolinska Institutet.; Karolinska Institutet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Alcohol use disorder (AUD) represent a major health problem worldwide. Despite the severe consequences of AUD, only four medications are approved in Sweden for this disease. In addition, the prescription rates are low, partly due to varying clinical efficacy of these medications. Consequently, new, more effective pharmacotherapies are needed. READ MORE