Search for dissertations about: "Pär Gerwins"

Found 5 swedish dissertations containing the words Pär Gerwins.

  1. 1. Directing Angiogenesis : Cellular Responses to Gradients in vitro

    Author : Irmeli Barkefors; Johan Kreuger; Lena Kjellén; Pär Gerwins; Ferdinand Le Noble; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Angiogenesis; Endothelial cell; Cell migration; Chemotaxis; Gradients; Microfluidics; VEGFA; VEGFR2; Exocyst; Exocytosis; Cell and molecular biology; Cell- och molekylärbiologi; Medical Biochemistry; Medicinsk biokemi;

    Abstract : Blood vessels are essential for the delivery of nutrients and oxygen to tissues, as well as for the removal of waste products. Patients with tumors, wounds or diabetes all have active angiogenesis, formation and remodeling of blood vessels, a process that is initiated and manipulated by gradients of secreted signaling proteins. READ MORE

  2. 2. Myofibroblasts and the Vascular Endothelium : Impact of Fibrin Degradation Products and miRNA on Vascular Motility and Function

    Author : Peder Fredlund Fuchs; Pär Gerwins; Johan Kreuger; Arne Östman; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; Angiogenesis; Vascular biology; Chemotaxis; Endothelial cell; Myofibroblast; Wound healing; miRNA; Heparan sulfate; Medical Science; Medicinsk vetenskap;

    Abstract : Angiogenesis is the formation of new blood vessels from pre-existing vasculature and is important during development as well as wound healing and tissue remodeling. Angiogenesis also occurs during pathological conditions such as diabetic retinopathy and cancer. READ MORE

  3. 3. Mechanisms of Tissue Vascularization

    Author : Witold Kilarski; Pär Gerwins; Lena Claesson-Welsh; Andreas Bikfalvi; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; vascularization; angiogenesis; granulation tissue; myofibroblast; wound healing; Patologi; Pathology; Patologi;

    Abstract : Tissue neovascularization in postnatal life occurs during post-traumatic tissue healing, neoplastic growth and in the endometrium during the reproductive cycle of females. Although embryonic angiogenesis has been intensively studied, far less is known about tissue revascularization and vessel remodeling in adults due to methodological difficulties. READ MORE

  4. 4. The Roles of Growth Factor Interactions and Mechanical Tension in Angiogenesis

    Author : Ludvig Petersson; Pär Gerwins; Filip Farnebo; Uppsala universitet; []
    Keywords : angiogenesis; myofibroblast; wound healing; VEGF; FGF; PDGF; endocan; endothelial cell; vascularization; MEDICINE; MEDICIN; Medicin; Medicine;

    Abstract : Angiogenesis, the formation of new blood vessels from preexisting ones through creation of new vessel branch points by sprouting or vessel splitting, is an important part of tissue growth in both physiological processes like wound healing and pathological conditions such as cancer. Growth factors like VEGF-A, FGF-2 and PDGF-BB are involved in both types of angiogenesis. READ MORE

  5. 5. Molecular Mechanisms in Endothelial Cell Differentiation

    Author : Emma Rennel; Pär Gerwins; Lena Claesson-Welsh; Ian Zachary; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; angiogenesis; FGF-2; VEGF-A; signal transduction; in vitro angiogenesis assay; immortalized brain endothelial cells; H-Ras; tetracycline-regulated gene expression; microarray; telomerase immortalized human microvascular endothelial cells; differentiation; Patologi; Pathology; Patologi;

    Abstract : Angiogenesis is the formation of new blood vessels from the pre-existing blood vessels. Blood vessels are composed of endothelial cells and supporting musculature. Angiogenesis is regulated by numerous soluble ligands and by cell-matrix interactions. READ MORE