Search for dissertations about: "P domain"

Showing result 1 - 5 of 185 swedish dissertations containing the words P domain.

  2. 1. Optimization of time domain induced polarization data acquisition and spectral information content

    Author : P.-I. Olsson; Teknisk geologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; induced polarization 1P ; DCIP; spectral information; Data quality; Signal Processing;

    Abstract : The need for detailed subsurface information is increasing due to city expansion and infill projects as well as subsurface construction projects. One common method for acquiring this geo-information is the direct current resistivity and time domain induced polarization method (DCIP) that measures the electrical resistivity and chargeability of the subsurface. READ MORE

  4. 2. Antibiotic Resistance and the Cellular Currency S-adenosyl-methionine : Modification of aminoglycosides and nucleic acids

    Author : Sandesh Kanchugal P; Maria Selmer; Ditlev Brodersen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance; streptomycin; spectinomycin; X-ray crystallography; methyltransferase; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Abstract : Streptomycin and spectinomycin are antibiotics that bind to ribosomes and inhibit protein synthesis. Common resistance mechanisms involve enzymatic modification of the two drugs by aminoglycoside nucleotidyltransferases (ANTs). The first part of this thesis covers the structural mechanism of two ANT enzymes. READ MORE

  5. 3. WNT/FZD signaling : an odyssey from molecular pharmacology to brain (patho)physiology

    Author : Jacomijn P Dijksterhuis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The 19 members of the lipoglycoprotein family of WNTs interact with the highly conserved cysteine-rich domain (CRD) of ten members of the Frizzled (FZD1-10) family. The seven transmembrane-spanning surface receptors are listed as G protein-coupled receptors and are known to interact with heterotrimeric G proteins as well as the scaffolding protein disheveled. READ MORE

  6. 4. The role of PDGFB in dermatofibrosarcoma protuberans and giant cell fibroblastoma

    Author : Kevin P O'Brien; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dermatofibrosarcoma protuberans; giant cell fibroblastoma; translocation; FISH; translocation breakpoint; fusion gene; oncogene; Platelet derived growth factor B-chain; collagen type I alpha 1; tumor formation; autocrine stimulation;

    Abstract : Dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) are rare invasive tumors of the dermis. GCF is considered the juvenile form of DFSP. Both DFSP and GCF are characterized by the presence of chromosomal aberrations involving chromosomes 17 and 22. READ MORE

  7. 5. The role of Notch signaling in cancer and metastasis

    Author : Anders P Mutvei; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The Notch signaling pathway is an evolutionary conserved cell-to-cell communication pathway that regulates many important aspects in the development and tissue homeostasis of multicellular animals. It operates in a wide range of cellular contexts and dysregulated Notch signaling has been linked to a number of diseases, including cancer. READ MORE