Search for dissertations about: "P-glycoprotein Pgp"

Showing result 11 - 15 of 18 swedish dissertations containing the words P-glycoprotein Pgp.

  2. 11. Expression of Genes Encoding for Drug Metabolism in the Small Intestine

    Author : Monica Lindell; Hans Lennernäs; Matti Lang; Olavi Pelkonen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; CYPs; UGTs; interindividual variation; small intestine; human; rat; artemisinin; CAR-receptor regulation; Farmaceutisk biokemi; Pharmaceutical biochemistry; Farmaceutisk biokemi;

    Abstract : This investigation focused on the mRNA expression of drug metabolising Cytochromes P-450 (CYP) and UDP-glucuronosyltransferases (UGT) and the transport protein P-glycoprotein (Pgp) in the small intestine of humans and rats.The mRNA expression of the investigated genes in the human small intestine (duodenum) varies between individuals giving each one of us personal profile. READ MORE

  4. 12. Drug transport and metabolism in in vitro models of the human intestine : By Shamsi D. Raeissi

    Author : Shamsi D. Raeissi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : The objective of this thesis was to study the mechanisms of drug transport and metabolism in two different in vitro models of the human intestine: monolayers of human intestinal epithelial cell lines and intestinal microsomes. The first part of the thesis shows that Caco-2 cell monolayers are a good model for mechanistic studies of drug transport. READ MORE

  5. 13. Experimental studies on multidrug resistance in human leukaemia : role of cellular heterogeneity for daunorubicin kinetics

    Author : Eva Knaust; Curt Peterson; Anna Porwit-MacDonald; Astrid Gruber; Christer Paul; Linköpings universitet; []
    Keywords : Acute myeloid leukaemia; heterogeneity; multidrug resistance. transport kinetics flow cytometry; gene expression; mdr1; mrp; lrp; apoptosis. bcl-2; p53; MEDICINE; MEDICIN;

    Abstract : Cellular resistance to chemotherapy is a major cause of treatment failure in acute myeloid leukaemia (AML) and still the majority of the patients die from their disease. Drug resistance 1s multifactorial, the most studied mechanism being multidrug resistance (MDR), mediated by the P-glycoprotein (Pgp). READ MORE

  6. 14. Intestinal transport and hepatic extraction of fluvastatin in humans and rats

    Author : Anders Lindahl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : The oral route is the most convenient route of delivering drugs intended to have systemic effects. One of the key variables determining the rate and extent of absorption from the gastrointestinal tract is the intestinal permeability to the drug. READ MORE

  7. 15. Heterogeneity of leukemic cells with regard to daunorubicin accumulation and efflux : potential role in drug resistance

    Author : Eva Knaust; Linköpings universitet; []
    Keywords : Drug resi stance. acute myeloid leukemia; flow cytometry; gene expression; transport kinetics; apoptosis; MEDICINE; MEDICIN;

    Abstract : Cellular resistance to chemotherapy is a major cause of treatment failure in acute myelocytic leukemia (AML) and other malignancies. Drug resistance is multifactorial; the most studied mechanism being multidrug resistance (MDR), mediated by the P-glycoprotein (PPG), a transmembrane transport protein with a pump function, encoded by the mdr 1 gene. READ MORE