Search for dissertations about: "P-glycoprotein"

Showing result 1 - 5 of 48 swedish dissertations containing the word P-glycoprotein.

  1. 1. P-glycoprotein and chiral antidepressant drugs Pharmacokinetic, pharmacogenetic and toxicological aspects

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Louise Karlsson; Linköpings universitet.; Linköpings universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The blood-brain barrier (BBB) is formed by the capillary endothelial cells, joined together by tight junctions, with transporter proteins. BBB acts to regulate the brain concentrations of substances including many drugs. READ MORE

  2. 2. Clinical studies of CYP3A4 and P-glycoprotein

    University dissertation from Stockholm : Karolinska Institutet, Dept of Laboratory Medicine

    Author : Erik Sparve; Karolinska Institutet.; Karolinska Institutet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : In the field of pharmacokinetics, cytochrome P450 enzymes have been extensively studied. The CYP450 enzyme with the most drug substrates is CYP3A4, but despite its significance, administration of a specific substrate to subjects is required to determine its activity, by measuring the metabolic ratio. READ MORE

  3. 3. ATP-Binding Cassette Efflux Transporters and Passive Membrane Permeability in Drug Absorption and Disposition

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Pär Matsson; Uppsala universitet.; [2007]
    Keywords : Pharmaceutics; ATP-binding cassette; ABC transporter; P-gp; P-glycoprotein; ABCB1; BCRP; Breast cancer resistance protein; ABCG2; MRP2; Multidrug-resistance associated protein 2; ABCC2; Membrane permeability; Drug transport; Active transport; Passive diffusion; Multivariate data analysis; PLS; OPLS; QSAR; Galenisk farmaci;

    Abstract : Transport into and across the cells of the human body is a prerequisite for the pharmacological action of drugs. Passive membrane permeability and active transport mechanisms are major determinants of the intestinal absorption of drugs, as well as of the distribution to target tissues and the subsequent metabolism and excretion from the body. READ MORE

  4. 4. ATP-Binding-Cassette Transporters in Biliary Efflux and Drug-Induced Liver Injury

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Jenny M. Pedersen; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABC transport protein; Pgp; P-glycoprotein; ABCB1; BCRP; breast cancer resistance protein; ABCG2; MRP2; multidrug resistance-associated protein 2; ABCC2; BSEP; bile salt export pump; ABCB11; sandwich cultured human hepatocytes; SCHH; drug-induced liver injury; DILI; multivariate data analysis; OPLS; Galenisk farmaci; Pharmaceutics;

    Abstract : Membrane transport proteins are known to influence the absorption, distribution, metabolism, excretion and toxicity (ADMET) of drugs. At the onset of this thesis work, only a few structure-activity models, in general describing P-glycoprotein (Pgp/ABCB1) interactions, were developed using small datasets with little structural diversity. READ MORE

  5. 5. Drug Transport and Metabolism in Rat and Human Intestine

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sofia Berggren; Uppsala universitet.; [2006]
    Keywords : Biopharmacy; Ussing chamber; microsome; single-pass perfusion; human; rat; intestine; permeability; efflux; P-glycoprotein; metabolism; cytochrome P450; ropivacaine; lidocaine; bupivacaine; Biofarmaci; PPX;

    Abstract : One of the aims of this thesis was to investigate the involvement of efflux proteins, such as the P-glycoprotein (Pgp), in the drug transport in different regions of the rat and the human intestine. The intestinal extrusion of intracellularly formed CYP3A4 metabolites, including whether this extrusion might be mediated by Pgp, was also studied. READ MORE