Search for dissertations about: "P-selectin."

Showing result 11 - 15 of 52 swedish dissertations containing the word P-selectin..

  2. 11. On Microvascular Inflammation and Intestinal Leakage in Radiation Enteropathy

    Author : Andrada Röme; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radiation; colon; intestinal leakage; Leukocyte and platelet recruitment;

    Abstract : Gastrointestinal tract damage is an insidious feature in patients undergoing radiotherapy. Microvascular inflammation, including leukocyte and platelet recruitment as well as epithelial barrier dysfunction, are considered to constitute key components in the pathophysiology of radiation-induced enteropathy. READ MORE

  4. 12. On leukocyte recruitment in endotoxemic liver injury

    Author : Daniel Klintman; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ortopedi; traumatology; Kirurgi; orthopaedics; Surgery; Sepsis; Liver; Inflammation; Adhesion; Endotoxemia; traumatologi;

    Abstract : Leukocyte recruitment is a key feature of liver injury associated with endotoxemia and systemic inflammation. The aim of this thesis was to define the adhesive mechanisms underlying leukocyte endothelial cell interactions, and the therapeutic potential of interference with specific adhesion molecules in endotoxemic liver damage. READ MORE

  5. 13. Role of adhesion molecules and chemokines in TNF-alpha-induced leukocyte recruitment

    Author : Xiao Wei Zhang; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; intravital microscopy; microcirculation; inflammation; adhesion; leukocyte; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Abstract : Migration of leukocytes from the circulating blood into the extravascular tissue is a key component in inflammatory reactions. Leukocyte extravasation (rolling-activation-adhesion-transmigration) is strictly coordinated by adhesion molecules and chemokines expressed on cell surfaces and in tissues. READ MORE

  6. 14. Platelet dysfunction in diabetes mellitus : impact of hyperglycemia and glycoprotein GPIIb/IIIa inhibition

    Author : Masoud Razmara; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Diabetes mellitus (DM) is associated with increased cardiovascular morbidity and mortality, due to diabetic angiopathy. Hyperglycemia is one of the factors that may cause platelet dysfunction in diabetic patients. This work investigated mechanisms underlying hyperglycemia-induced platelet dysfunction, and its impact in DM patients. READ MORE

  7. 15. Interactions between leukocytes, platelets and the endothelium in vein graft failure

    Author : Chi-Nan Tseng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Autologous venous grafts are preferred conduits in bypass surgery due to their length, easy harvesting, and feasibility. However, development of intimal hyperplasia decreases long-term patency rate in venous grafts prompting close clinical surveillance and further intervention. READ MORE