Search for dissertations about: "P.falciparum"
Showing result 16 - 20 of 103 swedish dissertations containing the word P.falciparum.
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16. Inhibitors of Human and Malaria Parasite Dihydroorotate Dehydrogenase
Abstract : In the first part of the PhD work, small chemical entities (fragments) found to inhibit human dihydroorotate dehydrogenase (DHODH), were chemically optimized. As part of an ample program at Active Biotech to find new drugs against autoimmune diseases, expanded fragments were repeatedly designed, synthesized and evaluated in a human DHODH assay. READ MORE
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17. Plasmodium falciparum response to chloroquine and artemisinin based combination therapy (ACT) in Guinea-Bissau
Abstract : Plasmodium falciparum causes the most severe form of malaria and is the most common malaria species in sub-Saharan Africa. Chloroquine used to be the most common drug for the treatment of malaria. Due to development of resistance, chloroquine is no longer efficacious in most of the world. The first line option for treatment of P. READ MORE
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18. Immunity to malaria: importance of exposure and parasite polymorphism
Abstract : Malaria continues to carry an intolerable burden of disease and mortality, predominantly on children in Sub-Saharan Africa. An efficacious vaccine would be a powerful tool in the combat against malaria. READ MORE
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19. Immunological characteristics of a C-terminal fragment of the Plasmodium falciparum blood-stage antigen Pf332
Abstract : Till date, there are no effective control strategies against the deadly disease of malaria, and millions of children across Africa, Oceania, Asia, and Latin America are at the mercy of this long term enemy of man every second that passes by. Other control measures combined with vaccination might help improve control strategy against malaria, but the development of vaccines face various challenges as well, due to the complexity of the parasites’ life cycle and other host factors. READ MORE
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20. Periodontal disease in adolescents with Down syndrome
Abstract : Characterization of virulence factors in P. falciparum malaria is essential in order to identify new therapeutic and prophylactic targets. Rosette formation, the binding of uninfected red blood cells to parasite-infected red blood cells, is a P. falciparum virulence phenotype associated with severe clinical manifestations, e. READ MORE