Search for dissertations about: "P14"

Showing result 1 - 5 of 9 swedish dissertations containing the word P14.

  2. 1. Molecular basis for enhanced T-cell recognition and cross-reactivity

    Author : Eva Allerbring; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : T cells of the adaptive immune system recognize and kill infected cells by interacting with pathogenic peptides displayed on major histocompatibility complexes (MHC) through its T-cell receptor (TCR). TCR interactions with peptide/MHC complexes occur throughout the lifespan of T cells, from development to activation, with the origin of the peptide varying between self and foreign. READ MORE

  4. 2. Functional screening and molecular characterisation of small proteins

    Author : Dörte Schlesinger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Proteins are one of the main drivers of cellular function. Most known proteins constitute various hundred amino acids, but growing evidence suggests that additionally thousands of short open reading frames (sORFs) are translated, posing the exciting possibility that many small unknown proteins are yet to be discovered. READ MORE

  5. 3. A microcell hybrid based 'elimination test' in the search for malignancy related genes

    Author : Stephan Imreh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis is focused on the elimination test developed by us (Imreh et al, 1994). The elimination test was designed as a functional test for malignancy related gene identification. Its task is to follow the cytogenetic and molecular alterations on single normal chromosomes transferred into tumor cells. READ MORE

  6. 4. Molecular aspects of tumor development and treatment for small intestinal neuroendocrine tumors

    Author : Omid Fotouhi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Small intestinal neuroendocrine tumors (SI-NETs) may cause symptoms due to excess secretion of hormones and peptides. The molecular mechanisms behind development of SINETs are not well understood. Copy number alterations, especially loss of chromosome 18q, have been reported and recently p27 mutations were implicated in SI-NET tumorigenesis. READ MORE

  7. 5. Role of the CDKN2A and related cell cycle regulatory genes in melanoma and other human cancers

    Author : Johanna Smeds; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CDKN2A; ARF; p53; cell cycle regulation; mutation; melanoma; esophageal squamous cell carcinoma;

    Abstract : The main objective of this thesis has been to investigate the involvement of the CDKN2A (p16INK4a and p14ARF) and related cell cycle regulatory genes in melanoma and other types of human cancer. The CDKN2A gene represents a unique locus in the entire human genome. READ MORE