Search for dissertations about: "P2Y"

Showing result 1 - 5 of 12 swedish dissertations containing the word P2Y.

2. 1. ADP regulation of insulin secretion and beta-cell apoptosis

   Author : Chanyuan Tan; Kardiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; P2Y; β-cell; ADP; insulin; apoptosis; autocrine; ectonucleotidase;

   Abstract : The aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) through ectonucleotidase or ATP release under the effect of high glucose. The expression of the ADP receptors P2Y1 and P2Y13 were shown in both mouse pancreatic islets and isolated β-cells using real-time PCR quantification. READ MORE

4. 2. Genetic studies on cardiovascular disease - identification of novel drug targets

   Author : Stefan Amisten; Kardiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Medicin människa och djur ; Medicine human and vertebrates ; platelet; single nucleotide polymorphism; myocardial infarction; stent; G-protein coupled receptor; P2Y; cytogenetics; Genetik; cytogenetik; Cardiovascular system; Kardiovaskulära systemet;

   Abstract : The aim of this thesis was to identify novel potential drug targets of cardiovascular disease with a focus on G-protein coupled receptors. We identified a common genetic variant of the ATP receptor P2Y11, where an alanine is substituted with a threonine at position 87 of the P2Y11 receptor that increases the risk of developing acute myocardial infarction. READ MORE

5. 3. Regulatory Functions of the Juxtaglomerular Apparatus

   Author : Ruisheng Liu; Ole Skott; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; mesangial; desensitization; nitric oxide; calcium; P2Y receptor; macula densa; NaCl; luminal. microperfusion; angiotensin; Cellbiologi; Cell biology; Cellbiologi; Medicine; medicin;

   Abstract : The tubuloglomerular feedback mechanism is an important regulator in the juxtaglomerular apparatus and it detects flow dependent alterations in luminal NaCl concentration ([NaCl]) at the macula densa (MD) cell site via a Na+-K+-2Cl cotransporter. Signals are sent by the MD to adjust the afferent arteriole tone and altering release of renin. READ MORE

6. 4. Local Purinergic Control of Arteriolar Reactivity in Pancreatic Islets and Renal Glomeruli

   Author : Xiang Gao; Leif Jansson; Olle Hellberg; Uppsala universitet; []
   Keywords : afferent arteriole; islet arteriole; adenosine; A1 receptor; ATP; P2Y receptor; microperfusion; angiotensin II; type 2 diabetes; hypertension; oxidative stress; nitric oxide; tubuloglomerular feedback;

   Abstract : Local control of regional blood flow is exerted mainly through the arterioles. An adequate minute-to-minute regulation of blood perfusion of the kidney and the pancreas is obtained by the modulation of arteriolar reactivity, which will influence the organ function. READ MORE

7. 5. Lipid Signalling Dynamics in Insulin-secreting β-cells

   Author : Anne Wuttke; Anders Tengholm; Erik Gylfe; Louis Philipson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ATP; β-cell; diacylglycerol; insulin secretion; oscillations; PtdIns 4 P; PtdIns 4; 5 P2; protein kinase C; P2Y receptor; Medical Cell Biology; Medicinsk cellbiologi;

   Abstract : Certain membrane lipids are involved in intracellular signalling processes, among them phosphoinositides and diacylglycerol (DAG). They mediate a variety of functions, including the effects of nutrients and neurohormonal stimuli on insulin secretion from pancreatic β-cells. READ MORE