Search for dissertations about: "P450c21"

Found 3 swedish dissertations containing the word P450c21.

  2. 1. Molecular analysis of mutated P450c21 in congenital adrenal hyperplasia

    Author : Svetlana Lajic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Congenital adrenal hyperplasia; 21-hydroxylase deficiency; P450c21; itl vitro expression; COS- I; functional analysis; prenatal treatment;

    Abstract : Defects in cytochrome P450c21 (21-hydroxylase, 210H) are the most common causes of congenital adrenal hyperplasia (CAH). This recessively inherited disorder demonstrates a wide spectrum of severity as a consequence of impaired production of cortisol and aldosterone and excessive secretion of adrenal androgens. READ MORE

  4. 2. Humoral immunity to recombinant human autoantigens in organ-specific autoimmune disease

    Author : Alberto Falorni; Karolinska Institutet; Karolinska Institutet; []
    Keywords : IDDM; Addison s disease; autoantibodies; recombinant autoantigens; radioimmunoassay; disease prediction; glutamic-acid decarboxylase; steroid-21-hydroxylase;

    Abstract : Insulin-dependent diabetes mellitus (IDDM) and idiopathic Addison's disease are organ-specific autoimmune diseases characterized by the presence of circulating autoantibodies. The role of autoantibodies in the pathogenesis of these diseases is not fully understood, but their presence can be used as a marker for diagnosis and prediction. READ MORE

  5. 3. Effects of endocrine disruptors on adreno-cortical and Leydig cell steroidogenesis

    Author : Vichit Supornsilchai; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Endocrine disrupting chemicals EDCs ; steroidogenesis; Leydig cells; adrenocortical cells; steroidogenic acute regulatory protein StAR ; steroidogenic enzymes;

    Abstract : A common sequential pathway for steroidogenesis, designed to produce steroid hormones, is expressed in the adrenal cortex, testes and ovaries. In this process, cholesterol is converted to all known steroids by specific enzymes in a tissue-specific manner. READ MORE