Search for dissertations about: "P53"

Showing result 1 - 5 of 356 swedish dissertations containing the word P53.

  1. 1. Radiosensitivity in lung cancer with focus on p53

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Michael Bergqvist; Uppsala universitet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Lung cancer; comet assay; p53; cDNA; p53 antibodies; Lungcancer; Komet metoden; p53 antikroppar; Onkologi; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; Oncology; onkologi;

    Abstract : In Sweden approximately 2800 new lung cancer patients are diagnosed every year. Radiotherapy is used with curative intention in certain groups of patients. The aim of this thesis is to study the basis of differences in radioresistance and the possibility to predict response to radiotherapy. READ MORE

  2. 2. p53 Alterations in Human Skin A Molecular Study Based on Morphology

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ling Gao; Uppsala universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; p53; skin; mutation; carcinogenesis; microdissection; UV; Basal cell cancer BCC ; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; Pathology; patologi;

    Abstract : Mutation of the p53 gene appears to be an early event in skin cancer development. The present study is based on morphology and represents a cellular and genetic investigation of p53 alterations in normal human skin and basal cell cancer. READ MORE

  3. 3. Pathophysiological impact of targeting the ROS-p53 axis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Volkan I. Sayin; Göteborgs universitet.; Gothenburg University.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antioxidants; Cancer; p53; ROS; atherosclerosis;

    Abstract : The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using molecular biology and biochemical techniques together with mouse genetics and bioinformatics. READ MORE

  4. 4. DNA repair and the p53 pathway in ischemic and traumatic brain injury

    University dissertation from Experimental Brain Research, Lund University

    Author : Gregor Tomasevic; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuronal death; DNA repair; knock-out mice; XPA; p53; mRNA; hippocampus; preconditioning; hypothermia; trauma; Brain; ischemia; neurobehavior; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Ischemic and traumatic brain damage are major causes of disability and death. While much effort has been spent to develop pharmacological treatments for these conditions, no neuroprotective drugs are in clinical use. READ MORE

  5. 5. On the function of the interferon-inducible p53 target gene TRIM22

    University dissertation from Division of Haematology and Transfusion Medicine

    Author : Jessica Petersson; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TRIM22; Staf50; p53; IFN; translation; proliferation; cell death;

    Abstract : The interferon-inducible p53-target gene TRIM22 (Staf50) is a member of the TRIM (TRIpartite Motif) family. The TRIM family is a family of RING (Really Interesting New Gene) proteins, defined through a tripartite motif, containing a RING-domain, one or two B-boxes and a Coiled-coil-domain. READ MORE