Search for dissertations about: "PAC1"

Showing result 1 - 5 of 7 swedish dissertations containing the word PAC1.

2. 1. PACAP in adult sensory neurons - implications in injury and pain

   Author : Helen Jongsma Wallin; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peripheral nerve injury; PAC1; PACAP; neurotrophin; neuropeptide; inflammatory pain; inflammation; gracile nuclei; DRG; formalin test; neurofysiologi; neuropsykologi; Neurologi; neurophysiology; neuropsychology; Neurology; trk;

   Abstract : The data presented in this thesis deal with the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) in adult sensory neurons. We have used different injury and pain models to determine the involvement of PACAP during such conditions. The role of neurotrophins for PACAP expression was also investigated. READ MORE

4. 2. PACAP and orphanin FQ/nociceptin -Distribution, importance and regulation in sensory neurons and spinal cord

   Author : Lina Pettersson; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; Neurology; trk; spinal cord; sensory neuron; rat; PAC1; PACAP; ORL1; OFQ N; neurotrophin; neuropeptide; nerve transection; nerve compression; inflammatory pain; BDNF; DRG;

   Abstract : Neuropeptide expression in the nervous system is abundant and plastic, and an altered expression after injury is an example of a functional response, helping the neuron to cope with adverse changes, and involves effects on differentiation, synthesis, repair/regeneration, survival, and modulation of signal transmission. I have investigated the distribution/expression of the neuropeptides, orphanin FQ/nociceptin (OFQ/N) and pituitary adenylate cyclase activating polypeptide (PACAP), under normal conditions, in response to nerve injuries, and also studied sensory responses in mice deficient for the PAC1 receptor (PAC1-/-). READ MORE

5. 3. The neuropeptides GRP and PACAP and the function of the endocrine pancreas - A study on receptor deficient mice

   Author : Kristin Persson; Lund Medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; hypoglycemia; glucagon; insulin; islet of Langerhans; diabetes; PACAP; neuropeptides; GRP; diabetologi;

   Abstract : The parasympathetic nerves are important for the regulation of insulin secretion, in particular after meal intake. Apart from acetylcholine, several neuropeptides can be found in the parasympathetic nerves innervating the islets of Langerhans, including gastrin-releasing peptide (GRP) and pituitary adenylate cyclase activating polypeptide (PACAP). READ MORE

6. 4. Vascular effects of neuropeptides and UDP-β-S and alterations after stroke

   Author : André Erdling; Neurokirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : The aim of this thesis is to investigate the changes in vasoactive intestinal peptide (VIP) and calcitonin gene-related peptide(CGRP) and P2Y6-mediated signaling following experimental subarachnoid hemorrhage (SAH) and transient middle cerebral artery occlusion (tMCAO). VIP and CGRP are among the most powerful vasodilators known to man while P2Y6 mediates strong vasoconstriction in cerebral blood vessels. READ MORE

7. 5. The Gastrin-ECL Cell Axis. Functional Aspects

   Author : Maria Björkqvist; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Pharmacological sciences; Calcium channels; CCK receptor antagonists; Misoprostol; Galanin; Somatostatin; Pancreastatin; Histamine; VIP; Gastrin; PACAP;

   Abstract : The ECL cells constitute a prominent endocrine cell population in the acid-producing part of the stomach. They are controlled by circulating gastrin released from G-cells in the antrum. In response to gastrin, they secrete histamine, that in turn stimulates the parietal cell to secrete acid. READ MORE