Search for dissertations about: "PATHOGEN BACTERIA"

Showing result 1 - 5 of 263 swedish dissertations containing the words PATHOGEN BACTERIA.

2. 1. Disarming bacteria : a structure-based approach to design an anti-virulence drug against Listeria monocytogenes

   Author : Melanie Oelker; A. Elisabeth Sauer-Eriksson; Fredrik Almqvist; Karina Persson; Tiziano Tuccinardi; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistances; anti-virulence drug; Listeria monocytogenes; virulence regulation; PrfA; structure-based drug design; ring-fused 2-pyridones; allosteric regulation; Biochemistry; biokemi; medicinal chemistry; läkemedelskemi; molekylär cellbiologi; molecular cell biology; medicinsk biokemi; Medical Biochemistry; molekylärbiologi; Molecular Biology;

   Abstract : Antibiotic resistances are one of the biggest threats to global health and if we don’t change our behavior and way of using antibiotics we will end up in a ‘post-antibiotic era’, in which common infections and minor injuries can once kill again and up to 10 million deaths per year may occur by 2050. Therefore, there is a high need for new anti-bacterial drugs, especially of alternatives to existing antibiotics with already described resistances. READ MORE

4. 2. Interaction Between Drosophila melanogaster mbn-2 Cells and Bacteria

   Author : Karin Johansson; Kenneth Söderhäll; Lage Cerenius; Martin Bilej; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell biology; Drosophila; innate immunity; bacteria; host - pathogen interaction; Cellbiologi; Cell biology; Cellbiologi;

   Abstract : Innate immunity relies on a repertoire of germline-encoded non-rearranging pattern recognition receptors that bind to invariant microbial surface molecules. This event initiates a number of signal transduction cascades that lead to humoral and cellular defense responses like synthesis of antimicrobial peptides, phagocytosis and coagulation – mechanisms that efficiently fight infectious microorganisms and have been evolutionary conserved to exist in parallel with the antibody-based adaptive immunity found in vertebrates. READ MORE

5. 3. Comparative analysis of pathogen occurrence in wastewater : management strategies for barrier function and microbial control

   Author : Jakob Ottoson; Bengt Hultman; Roland Schertenleib; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; bacteria; parasites; treatment; Water engineering; Vattenteknik;

   Abstract : This project was initiated to fill knowledge gaps on the occurrence of pathogens in different streams of wastewater, e.g. greywater and domestic wastewater. READ MORE

6. 4. Evolutionary Processes and Genome Dynamics in Host-Adapted Bacteria

   Author : Björn Nystedt; Siv Andersson; David Guttman; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; molecular evolution; pathogen; secretion system; Bartonella; Buchnera; Blochmannia; Helicobacter; Bioinformatics; Bioinformatik; Evolutionary Genetics; evolutionär genetik;

   Abstract : Many bacteria live in close association with other organisms such as plants and animals, with important implications for both health and disease. This thesis investigates bacteria that are well adapted to live inside an animal host, and describes the molecular evolutionary processes underlying host-adaptation, based on bacterial genome comparisons. READ MORE

7. 5. Nucleic Acid Based Pathogen Diagnostics

   Author : Michael S. Akhras; Pål Nyrén; Nader Pourmand; Mats Nilsson; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; pathogen diagnostics; antibiotic resistance; connector inversion probes CIPer ; human papillomavirus HPV ; genotyping; global health diagnostic forum; molecular inversion probe MIP ; neisseria gonorrhoeae; padlock probes; pyrosequencing; Biochemistry; Biokemi;

   Abstract : Pathogenic organisms are transmitted to the host organism through all possible connected pathways, and cause a myriad of diseases states. Commonly occurring curable infectious diseases still impose the greatest health impacts on a worldwide perspective. READ MORE